N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)but-1-ynyl]nicotinamide

Base Information

Chemical Name:N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)but-1-ynyl]nicotinamide
CAS No.:1246609-53-9
Molecular Formula:C₂₄H₂₄N₆O₂
Molecular Weight:428.494
Hs Code.:

Synonyms:N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)but-1-ynyl]nicotinamide

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Chemical Property of N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)but-1-ynyl]nicotinamide

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Technology Process of N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)but-1-ynyl]nicotinamide

There total 4 articles about N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)but-1-ynyl]nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1138322-10-7
6-chloro-N-methyl-2-(phenylamino)nicotinamide

: 1246609-89-1
1-but-3-ynyl-3-pyridin-3-ylmethylurea

: 1246609-53-9
N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)but-1-ynyl]nicotinamide

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; at 90 ℃; for 12h; Inert atmosphere;

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1246609-53-9
N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)but-1-ynyl]nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 75 °C

1.2: 15 h / 20 °C

1.3: pH 2

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 15 h / 20 °C

3.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; N,N-dimethyl-formamide; 3.1: Sonogashira Coupling;

Reference yield:

: 1138322-09-4
6-Chloro-2-(phenylamino)nicotinic acid

: 1246609-53-9
N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)but-1-ynyl]nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 15 h / 20 °C

2: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Sonogashira Coupling;