N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)butyl]-nicotinamide

Base Information

Chemical Name:N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)butyl]-nicotinamide
CAS No.:1246609-46-0
Molecular Formula:C₂₄H₂₈N₆O₂
Molecular Weight:432.525
Hs Code.:

Synonyms:N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)butyl]-nicotinamide

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Chemical Property of N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)butyl]-nicotinamide

Chemical Property:

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Technology Process of N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)butyl]-nicotinamide

There total 5 articles about N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)butyl]-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1246609-53-9
N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)but-1-ynyl]nicotinamide

: 1246609-46-0
N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)butyl]-nicotinamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; under 760.051 Torr;

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1246609-46-0
N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)butyl]-nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 75 °C

1.2: 15 h / 20 °C

1.3: pH 2

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 15 h / 20 °C

3.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 3.1: Sonogashira Coupling;

Reference yield:

: 1138322-09-4
6-Chloro-2-(phenylamino)nicotinic acid

: 1246609-46-0
N-methyl-2-phenylamino-6-[4-(3-pyridin-3-ylmethylureido)butyl]-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 15 h / 20 °C

2: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 2: Sonogashira Coupling;