(7S,10R)-11-tert-butyl 5-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate

Base Information

Chemical Name:(7S,10R)-11-tert-butyl 5-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate
CAS No.:1287297-07-7
Molecular Formula:C₂₉H₃₉BrN₂O₄
Molecular Weight:559.544
Hs Code.:

(7S,10R)-11-tert-butyl 5-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate

Synonyms:(7S,10R)-11-tert-butyl 5-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate

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Chemical Property of (7S,10R)-11-tert-butyl 5-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate

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Technology Process of (7S,10R)-11-tert-butyl 5-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate

There total 7 articles about (7S,10R)-11-tert-butyl 5-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 11-tert-butyl 5-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate

: 1287297-07-7
(7S,10R)-11-tert-butyl 5-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In hexane; at -5 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetasy.2012.10.012

Reference yield:

: 11-tert-butyl 5-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate

: 1287297-08-8
tert-butyl 2-bromo-5-[(1lR,2S,5R)-2-isopropyl-5-methylcyclohexyl]-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-carboxylate

: 1287297-07-7
(7S,10R)-11-tert-butyl 5-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate

Guidance literature:: In hexane; at -5 ℃; for 72h; Resolution of racemate;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1287297-08-8
tert-butyl 2-bromo-5-[(1lR,2S,5R)-2-isopropyl-5-methylcyclohexyl]-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-carboxylate

: 1287297-07-7
(7S,10R)-11-tert-butyl 5-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / isopropyl alcohol; water / 2 h / 0 °C

2: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 8 h / 20 °C

3: hexane / 72 h / -5 °C / Resolution of racemate

With potassium carbonate; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In hexane; dichloromethane; water; isopropyl alcohol;