(7S,10R)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole

Base Information

• Chemical Name: (7S,10R)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole
• CAS No.: 1287375-04-5
• Molecular Formula: C₂₁H₁₉F₃N₂O₂S
• Molecular Weight: 420.455

Synonyms:(7S,10R)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole

Chemical Property of (7S,10R)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (7S,10R)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole

There total 8 articles about (7S,10R)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(7S,10R)-tert-butyl 5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-11-carboxylate (1416007-20-9) → (7S,10R)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole (1287375-04-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetasy.2012.10.012

Reference yield:

(7S,10R)-11-tert-butyl 5-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate (1287297-07-7) → (7S,10R)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole (1287375-04-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hydroxide monohydrate / methanol; water; tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 4 h / 120 °C / Inert atmosphere

4.1: hydrogenchloride / water; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; sodium hydride; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1016/j.tetasy.2012.10.012

Reference yield:

(7S,10R)-tert-butyl 2-bromo-5-methyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-11-carboxylate (1287297-09-9) → (7S,10R)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole (1287375-04-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 4 h / 120 °C / Inert atmosphere

3.1: hydrogenchloride / water; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1016/j.tetasy.2012.10.012

upstream raw materials:

(7S,10R)-11-tert-butyl 5-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate

(7S,10R)-tert-butyl 2-bromo-5-methyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-11-carboxylate

(7S,10R)-tert-butyl 5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-11-carboxylate

4-bromophenylhydrazine hydrochloride

Downstream raw materials:

(7S,10R)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole hydrochloride

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