1-{4-[3,3-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-pentyloxy]-2-hydroxy-3-propyl-phenyl}-ethanone

Base Information

Chemical Name:1-{4-[3,3-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-pentyloxy]-2-hydroxy-3-propyl-phenyl}-ethanone
CAS No.:122443-70-3
Molecular Formula:C₂₃H₃₆O₅
Molecular Weight:392.536
Hs Code.:

Synonyms:1-{4-[3,3-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-pentyloxy]-2-hydroxy-3-propyl-phenyl}-ethanone

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Chemical Property of 1-{4-[3,3-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-pentyloxy]-2-hydroxy-3-propyl-phenyl}-ethanone

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Technology Process of 1-{4-[3,3-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-pentyloxy]-2-hydroxy-3-propyl-phenyl}-ethanone

There total 4 articles about 1-{4-[3,3-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-pentyloxy]-2-hydroxy-3-propyl-phenyl}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.2%

: 40786-69-4
1-(2,4-dihydroxy-3-propylphenyl)ethanone

: 122444-39-7
Methanesulfonic acid 3,3-dimethyl-5-(tetrahydro-pyran-2-yloxy)-pentyl ester

: 122443-70-3
1-{4-[3,3-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-pentyloxy]-2-hydroxy-3-propyl-phenyl}-ethanone

Guidance literature:: With potassium carbonate; 18-crown-6 ether; In acetonitrile; for 18h; Heating;
DOI:10.1021/jm00128a028

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 122443-70-3
1-{4-[3,3-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-pentyloxy]-2-hydroxy-3-propyl-phenyl}-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 20 percent / p-toluenesulfonic acid monohydrate / tetrahydrofuran / 18 h / Ambient temperature

2: 94.5 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

3: 58.2 percent / K₂CO₃ / 18-crown-6 / acetonitrile / 18 h / Heating

With potassium carbonate; toluene-4-sulfonic acid; triethylamine; 18-crown-6 ether; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm00128a028

Reference yield:

: 53120-74-4
3,3-dimethylpent-1,5-diol

: 122443-70-3
1-{4-[3,3-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-pentyloxy]-2-hydroxy-3-propyl-phenyl}-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 20 percent / p-toluenesulfonic acid monohydrate / tetrahydrofuran / 18 h / Ambient temperature

2: 94.5 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

3: 58.2 percent / K₂CO₃ / 18-crown-6 / acetonitrile / 18 h / Heating

With potassium carbonate; toluene-4-sulfonic acid; triethylamine; 18-crown-6 ether; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm00128a028