2-[4-(aminosulfonyl)benzoyl]-N-[4-(aminosulfonyl)phenyl]-1-hydrazinecarbothioamide

Base Information

• Chemical Name: 2-[4-(aminosulfonyl)benzoyl]-N-[4-(aminosulfonyl)phenyl]-1-hydrazinecarbothioamide
• CAS No.: 1580456-62-7
• Molecular Formula: C₁₄H₁₅N₅O₅S₃
• Molecular Weight: 429.502
• Mol file: 1580456-62-7.mol

Synonyms:2-[4-(aminosulfonyl)benzoyl]-N-[4-(aminosulfonyl)phenyl]-1-hydrazinecarbothioamide

Chemical Property of 2-[4-(aminosulfonyl)benzoyl]-N-[4-(aminosulfonyl)phenyl]-1-hydrazinecarbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(aminosulfonyl)benzoyl]-N-[4-(aminosulfonyl)phenyl]-1-hydrazinecarbothioamide

There total 6 articles about 2-[4-(aminosulfonyl)benzoyl]-N-[4-(aminosulfonyl)phenyl]-1-hydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-isothiocyanatobenzene sulfonamide (51908-29-3) + 4-(hydrazinecarbonyl)benzene-1-sulfonamide (35264-29-0) → 2-[4-(aminosulfonyl)benzoyl]-N-[4-(aminosulfonyl)phenyl]-1-hydrazinecarbothioamide (1580456-62-7)

Guidance literature:

In ethanol; Reflux;

DOI:10.1016/j.bmc.2014.01.055

Reference yield:

sulfanilamide (63-74-1) → 2-[4-(aminosulfonyl)benzoyl]-N-[4-(aminosulfonyl)phenyl]-1-hydrazinecarbothioamide (1580456-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 0.17 h / 0 °C

2: sodium hydrogencarbonate; iodine / ethyl acetate; water / Cooling with ice

3: ethanol / Reflux

With iodine; sodium hydrogencarbonate; In methanol; ethanol; water; ethyl acetate;

DOI:10.1016/j.bmc.2014.01.055

Reference yield:

toluene-4-sulfonamide (70-55-3) → 2-[4-(aminosulfonyl)benzoyl]-N-[4-(aminosulfonyl)phenyl]-1-hydrazinecarbothioamide (1580456-62-7)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium permanganate / water / Reflux

2: Reflux; Acidic conditions

3: hydrazine hydrate / methanol / Reflux

4: ethanol / Reflux

With potassium permanganate; hydrazine hydrate; In methanol; ethanol; water;

DOI:10.1016/j.bmc.2014.01.055

upstream raw materials:

sulfanilamide

triethylamine thiocarbamate

4-isothiocyanatobenzene sulfonamide

4-(hydrazinecarbonyl)benzene-1-sulfonamide

Downstream raw materials:

4-{3-[4-(aminosulfonyl)phenyl]-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}benzenesulfonamide