N-(3-(5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

Base Information

Chemical Name:N-(3-(5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
CAS No.:1246614-23-2
Molecular Formula:C₁₆H₁₃BrF₂N₄O₃S
Molecular Weight:459.271
Hs Code.:

Synonyms:N-(3-(5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

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Chemical Property of N-(3-(5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

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Technology Process of N-(3-(5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

There total 5 articles about N-(3-(5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 10147-36-1
n-propanesulfonyl chloride

: (3-amino-2,6-difluorophenyl)(5-bromo-1H-pyrazolo[3,4-b]pyridin-3-yl)methanone

: 1246614-23-2
N-(3-(5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

Guidance literature:: With dmap; at 65 ℃;
DOI:10.1016/j.ejmech.2021.113371

Reference yield:

: 916325-85-4
5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

: 1246614-23-2
N-(3-(5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / 0.75 h / 60 °C

1.2: 4 h / 65 °C

2.1: n-butyllithium / hexane / 0.25 h / -78 °C / Inert atmosphere

2.2: 0.5 h

3.1: dmap; pyridine / 2 h / 65 °C

With pyridine; dmap; n-butyllithium; 1,1'-carbonyldiimidazole; In hexane;

Reference yield:

: 875781-17-2,916257-29-9
5-bromo-7-azaindazole

: 1246614-23-2
N-(3-(5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 2 h / 20 - 45 °C

2.1: triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate / N,N-dimethyl-formamide; methanol / 8 h / 60 °C / Inert atmosphere

3.1: 1,1'-carbonyldiimidazole / 0.75 h / 60 °C

3.2: 4 h / 65 °C

4.1: n-butyllithium / hexane / 0.25 h / -78 °C / Inert atmosphere

4.2: 0.5 h

5.1: dmap; pyridine / 2 h / 65 °C

With pyridine; dmap; n-butyllithium; iodine; palladium diacetate; triethylamine; 1,1'-carbonyldiimidazole; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide; In methanol; hexane; N,N-dimethyl-formamide;