acetic acid 3-tert-butoxycarbonylamino-4-(3-methoxy-phenyl)-1-methylsulfanyl-2-oxo-butyl ester

Base Information

Chemical Name:acetic acid 3-tert-butoxycarbonylamino-4-(3-methoxy-phenyl)-1-methylsulfanyl-2-oxo-butyl ester
CAS No.:672965-04-7
Molecular Formula:C₁₉H₂₇NO₆S
Molecular Weight:397.492
Hs Code.:

acetic acid 3-<i>tert</i>-butoxycarbonylamino-4-(3-methoxy-phenyl)-1-methylsulfanyl-2-oxo-butyl ester

Synonyms:acetic acid 3-tert-butoxycarbonylamino-4-(3-methoxy-phenyl)-1-methylsulfanyl-2-oxo-butyl ester

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Chemical Property of acetic acid 3-tert-butoxycarbonylamino-4-(3-methoxy-phenyl)-1-methylsulfanyl-2-oxo-butyl ester

Chemical Property:

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Technology Process of acetic acid 3-tert-butoxycarbonylamino-4-(3-methoxy-phenyl)-1-methylsulfanyl-2-oxo-butyl ester

There total 5 articles about acetic acid 3-tert-butoxycarbonylamino-4-(3-methoxy-phenyl)-1-methylsulfanyl-2-oxo-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-24-7
acetic anhydride

: 672965-03-6
[3-methanesulfinyl-1-(3-methoxy-benzyl)-2-oxo-propyl]-carbamic acid tert-butyl ester

: 672965-04-7
acetic acid 3-tert-butoxycarbonylamino-4-(3-methoxy-phenyl)-1-methylsulfanyl-2-oxo-butyl ester

Guidance literature:: With pyridine; dmap; In dichloromethane; at 25 ℃; for 16h;
DOI:10.1016/j.bmc.2003.10.037

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 672965-04-7
acetic acid 3-tert-butoxycarbonylamino-4-(3-methoxy-phenyl)-1-methylsulfanyl-2-oxo-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran; H₂O

2.1: K₂CO₃ / dimethylformamide

3.1: sodium amide / tetrahydrofuran / 3 h / 50 °C

3.2: 59 percent / tetrahydrofuran / 2 h / 0 °C

4.1: 5.19 g / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / 25 °C

With pyridine; dmap; potassium carbonate; sodium amide; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 4.1: Pummerer rearrangement;
DOI:10.1016/j.bmc.2003.10.037

Reference yield:

: (S)-2-amino-3-(3-methoxyphenyl)propanoic acid

: 672965-04-7
acetic acid 3-tert-butoxycarbonylamino-4-(3-methoxy-phenyl)-1-methylsulfanyl-2-oxo-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran; H₂O

2.1: K₂CO₃ / dimethylformamide

3.1: sodium amide / tetrahydrofuran / 3 h / 50 °C

3.2: 59 percent / tetrahydrofuran / 2 h / 0 °C

4.1: 5.19 g / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / 25 °C

With pyridine; dmap; potassium carbonate; sodium amide; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 4.1: Pummerer rearrangement;
DOI:10.1016/j.bmc.2003.10.037