Boc-3-Methoxy-L-Phenylalanine

Base Information

• Chemical Name: Boc-3-Methoxy-L-Phenylalanine
• CAS No.: 261360-71-8
• Molecular Formula: C₁₅H₂₁NO₅
• Molecular Weight: 295.335
• Mol file: 261360-71-8.mol

Synonyms:Boc-3-Methoxy-L-Phenylalanine;BOC-L-3-MEO-PHE-OH;(S)-BOC-3-METHOXYPHENYLALANINE;BOC-PHE(3-OME)-OH;BOC-L-M-TYR(ME);

Chemical Property of Boc-3-Methoxy-L-Phenylalanine

Chemical Property:

• PSA: 88.35000
• LogP: 2.42000

Purity/Quality:

98%min ^*data from raw suppliers

Boc-L-Phe(3-OMe)-OH*DCHA ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boc-3-Methoxy-L-Phenylalanine

There total 2 articles about Boc-3-Methoxy-L-Phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ N-tert-butoxycarbonyl-3-methoxy-L-phenylalanine (261360-71-8,82278-99-7)

Guidance literature:

With potassium carbonate; In acetone; for 18h; Reflux;

With methanol; sodium hydroxide; at 40 ℃; for 3h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-amino-3-(3-methoxyphenyl)propanoic acid → N-tert-butoxycarbonyl-3-methoxy-L-phenylalanine (261360-71-8,82278-99-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; water;

DOI:10.1016/j.bmc.2003.10.037

Reference yield:

N-tert-butoxycarbonyl-3-methoxy-L-phenylalanine (261360-71-8,82278-99-7) → [3-methanesulfinyl-1-(3-methoxy-benzyl)-2-oxo-propyl]-carbamic acid tert-butyl ester (672965-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: K₂CO₃ / dimethylformamide

2.1: sodium amide / tetrahydrofuran / 3 h / 50 °C

2.2: 59 percent / tetrahydrofuran / 2 h / 0 °C

With potassium carbonate; sodium amide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2003.10.037

upstream raw materials:

di-tert-butyl dicarbonate

Downstream raw materials:

methyl (S)-2-((tert-butyloxycarbonyl)amino)-3-(3-methoxyphenyl)propanoate

[3-methanesulfinyl-1-(3-methoxy-benzyl)-2-oxo-propyl]-carbamic acid tert-butyl ester

(2S,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-(3-methoxyphenyl)butyric acid

acetic acid 3-tert-butoxycarbonylamino-4-(3-methoxy-phenyl)-1-methylsulfanyl-2-oxo-butyl ester

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