(+)-1-methylethyl 4-({7-[2-fluoro-4-(methylsulfonyl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

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Chemical Name:(+)-1-methylethyl 4-({7-[2-fluoro-4-(methylsulfonyl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate
CAS No.:1001398-43-1
Molecular Formula:C₂₃H₂₉FN₄O₅S
Molecular Weight:492.571
Hs Code.:

Synonyms:(+)-1-methylethyl 4-({7-[2-fluoro-4-(methylsulfonyl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

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Chemical Property of (+)-1-methylethyl 4-({7-[2-fluoro-4-(methylsulfonyl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

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Technology Process of (+)-1-methylethyl 4-({7-[2-fluoro-4-(methylsulfonyl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

There total 8 articles about (+)-1-methylethyl 4-({7-[2-fluoro-4-(methylsulfonyl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1001398-41-9,1416321-90-8,1416321-93-1
(+/-)-1-methylethyl 4-({7-[2-fluoro-4-(methylsulfonyl)phenyl]-6-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

: 1001398-42-0
(-)-1-methylethyl 4-({7-[2-fluoro-4-(methylsulfonyl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

: 1001398-43-1
(+)-1-methylethyl 4-({7-[2-fluoro-4-(methylsulfonyl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

Guidance literature:: With Chiralpak OJ; In methanol; chloroform; carbon dioxide; at 30 ℃; under 105011 Torr; Resolution of racemate;

Reference yield:

: 1001397-14-3
6-chloro-N-[2-fluoro-4-(methylsulfonyl)phenyl]-5-(2-propen-1-yl)-4-pyrimidinamine

: 1001398-42-0
(-)-1-methylethyl 4-({7-[2-fluoro-4-(methylsulfonyl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

: 1001398-43-1
(+)-1-methylethyl 4-({7-[2-fluoro-4-(methylsulfonyl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium osmate(VI) dihydrate; sodium periodate / water; acetone / 4 h

2.1: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

4.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 24 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / Reflux

5.2: 1.5 h / 20 °C / Reflux

6.1: carbon dioxide / methanol; chloroform / 30 °C / 105011 Torr / Resolution of racemate

With potassium osmate(VI) dihydrate; sodium periodate; carbon dioxide; sodium hydride; triethylamine; trifluoroacetic acid; Methanesulfonic anhydride; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; acetone;
DOI:10.1021/jm301404a

Reference yield:

: 16019-30-0
6-hydroxy-5-(2-propen-1-yl)-4(1H)-pyrimidinone

: 1001398-42-0
(-)-1-methylethyl 4-({7-[2-fluoro-4-(methylsulfonyl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

: 1001398-43-1
(+)-1-methylethyl 4-({7-[2-fluoro-4-(methylsulfonyl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: trichlorophosphate / 4 h / Inert atmosphere; Reflux

2.1: sodium hydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

3.1: potassium osmate(VI) dihydrate; sodium periodate / water; acetone / 4 h

4.1: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

6.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 24 h / 20 °C

7.1: sodium hydride / tetrahydrofuran / 0.5 h / Reflux

7.2: 1.5 h / 20 °C / Reflux

8.1: carbon dioxide / methanol; chloroform / 30 °C / 105011 Torr / Resolution of racemate

With potassium osmate(VI) dihydrate; sodium periodate; carbon dioxide; sodium hydride; triethylamine; trifluoroacetic acid; trichlorophosphate; Methanesulfonic anhydride; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; acetone;
DOI:10.1021/jm301404a