11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine

Base Information

Chemical Name:11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine
CAS No.:844639-08-3
Molecular Formula:C₂₈H₃₁N₃O₂S
Molecular Weight:473.639
Hs Code.:

Synonyms:11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine

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Technology Process of 11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine

There total 1 articles about 11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.8%

: 5786-26-5
11-aminodibenzo<1,4>thiazepine

: [2-(2-benzyloxy-ethoxy)-ethyl]bis-(2-chloroethyl)amine hydrochloride

: 844639-08-3
11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine

Guidance literature:: 11-aminodibenzo<1,4>thiazepine; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 40 ℃; for 0.25h;

[2-(2-benzyloxy-ethoxy)-ethyl]bis-(2-chloroethyl)amine hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 - 80 ℃; for 5h;

Reference yield: 89.0%

: 844639-08-3
11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine

: 64-19-7,77671-22-8
acetic acid

: 844639-07-2
11-[4-[2-(2-(2-acetyloxy)ethoxy)ethyl]-1-piperazinyl]dibenzo [b,f][1,4]thiazepine

Guidance literature:: 11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine; acetic acid; With hydrogen bromide; at 20 - 25 ℃; for 1.5h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 844639-08-3
11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine

: 111974-69-7
Quetiapine

Guidance literature:: 11-{4-[2-(2-benzyloxy-ethoxy)ethyl]-piperazin-1-yl}-dibenzo[b,f][1,4]thiazepine; With boron trichloride; In toluene; xylene; at -5 - 20 ℃; for 2h;

With triethylamine; In methanol; toluene; xylene; for 0.166667h;

With sodium hydroxide; In methanol; water; toluene; xylene; Product distribution / selectivity;