1-(3-{[2-(4-amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-(4-methyl-1-piperazinyl)-4-oxo-1-butanone

Base Information

• Chemical Name: 1-(3-{[2-(4-amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-(4-methyl-1-piperazinyl)-4-oxo-1-butanone
• CAS No.: 850664-14-1
• Molecular Formula: C₂₅H₂₈N₈O₄
• Molecular Weight: 504.549
• Mol file: 850664-14-1.mol

Synonyms:1-(3-{[2-(4-amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-(4-methyl-1-piperazinyl)-4-oxo-1-butanone

Chemical Property of 1-(3-{[2-(4-amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-(4-methyl-1-piperazinyl)-4-oxo-1-butanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-{[2-(4-amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-(4-methyl-1-piperazinyl)-4-oxo-1-butanone

There total 2 articles about 1-(3-{[2-(4-amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-(4-methyl-1-piperazinyl)-4-oxo-1-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

4-[6-bromo-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine (850663-86-4) + 1-(3-hydroxyphenyl)-4-(4-methyl-1-piperazinyl)-4-oxo-1-butanone (850664-16-3) → 1-(3-{[2-(4-amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-(4-methyl-1-piperazinyl)-4-oxo-1-butanone (850664-14-1)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In 1,2-dimethoxyethane; toluene; at 170 ℃; for 0.416667h; Microwave irradiation;

Reference yield:

1-methyl-piperazine (109-01-3) + 4-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)-4-oxobutanoic acid (850664-15-2) → 1-(3-{[2-(4-amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-(4-methyl-1-piperazinyl)-4-oxo-1-butanone (850664-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

2: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / 1,2-dimethoxyethane; toluene / 0.42 h / 170 °C / Microwave irradiation

With 4-methyl-morpholine; copper(l) iodide; 1,10-Phenanthroline; benzotriazol-1-ol; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

4-[6-bromo-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine

1-(3-hydroxyphenyl)-4-(4-methyl-1-piperazinyl)-4-oxo-1-butanone

1-methyl-piperazine

4-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)-4-oxobutanoic acid