4-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)-4-oxobutanoic acid

Base Information

Chemical Name:4-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)-4-oxobutanoic acid
CAS No.:850664-15-2
Molecular Formula:C₁₆H₂₄O₄Si
Molecular Weight:308.45
Hs Code.:

Synonyms:4-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)-4-oxobutanoic acid

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Chemical Property of 4-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)-4-oxobutanoic acid

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Technology Process of 4-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)-4-oxobutanoic acid

There total 1 articles about 4-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 108-30-5
succinic acid anhydride

: 65423-56-5
1-bromo-3-[(tert-butyldimethylsilyl)oxy]benzene

: 850664-15-2
4-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)-4-oxobutanoic acid

Guidance literature:: 1-bromo-3-[(tert-butyldimethylsilyl)oxy]benzene; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 0.333333h;

succinic acid anhydride; In tetrahydrofuran; hexanes; at -78 - 20 ℃;

Reference yield: 82.0%

: 109-01-3
1-methyl-piperazine

: 850664-15-2
4-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)-4-oxobutanoic acid

: 850664-16-3
1-(3-hydroxyphenyl)-4-(4-methyl-1-piperazinyl)-4-oxo-1-butanone

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 850664-15-2
4-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)-4-oxobutanoic acid

: 850664-14-1
1-(3-{[2-(4-amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-(4-methyl-1-piperazinyl)-4-oxo-1-butanone

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

2: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / 1,2-dimethoxyethane; toluene / 0.42 h / 170 °C / Microwave irradiation

With 4-methyl-morpholine; copper(l) iodide; 1,10-Phenanthroline; benzotriazol-1-ol; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene;