trifluoromethanesulfonic acid 1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl ester

Base Information

• Chemical Name: trifluoromethanesulfonic acid 1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl ester
• CAS No.: 1620885-37-1
• Molecular Formula: C₉H₄F₈O₃S
• Molecular Weight: 344.182
• Mol file: 1620885-37-1.mol

Synonyms:trifluoromethanesulfonic acid 1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl ester

Chemical Property of trifluoromethanesulfonic acid 1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl ester

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trifluoromethanesulfonic acid 1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl ester

There total 2 articles about trifluoromethanesulfonic acid 1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-(3,4-difluorophenyl)-2,2,2-trifluoroethanol (945978-37-0) + trifluoromethylsulfonic anhydride (358-23-6) → trifluoromethanesulfonic acid 1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl ester (1620885-37-1)

Guidance literature:

With 2,6-dimethylpyridine; In cyclohexane; at -10 - 10 ℃; for 2h; Inert atmosphere;

Reference yield:

1-(3,4-difluorophenyl)-2,2,2-trifluoroethanone (302912-28-3) → trifluoromethanesulfonic acid 1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl ester (1620885-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; methanol / 1 h / 20 °C

2: 2,6-dimethylpyridine / cyclohexane / 2 h / -10 - 10 °C / Inert atmosphere

With 2,6-dimethylpyridine; methanol; sodium tetrahydroborate; In cyclohexane;

Reference yield: 22.0%

trifluoromethanesulfonic acid 1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl ester (1620885-37-1) + C19H17BrF3N3O2 (1620885-22-4) → 7’-bromo-1-(1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl)-3’-(4-(trifluoromethoxy)phenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one (1620884-97-0)

Guidance literature:

With p-toluenesulfonic acid monohydrate; In toluene; at 140 ℃; for 2h;

upstream raw materials:

1-(3,4-difluorophenyl)-2,2,2-trifluoroethanol

trifluoromethylsulfonic anhydride

1-(3,4-difluorophenyl)-2,2,2-trifluoroethanone

Downstream raw materials:

7’-bromo-1-(1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl)-3’-(4-(trifluoromethoxy)phenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one