7’-bromo-1-(1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl)-3’-(4-(trifluoromethoxy)phenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one

Base Information

• Chemical Name: 7’-bromo-1-(1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl)-3’-(4-(trifluoromethoxy)phenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one
• CAS No.: 1620884-97-0
• Molecular Formula: C₂₇H₂₀BrF₈N₃O₂
• Molecular Weight: 650.366
• Mol file: 1620884-97-0.mol

Synonyms:7’-bromo-1-(1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl)-3’-(4-(trifluoromethoxy)phenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one

Chemical Property of 7’-bromo-1-(1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl)-3’-(4-(trifluoromethoxy)phenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7’-bromo-1-(1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl)-3’-(4-(trifluoromethoxy)phenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one

There total 3 articles about 7’-bromo-1-(1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl)-3’-(4-(trifluoromethoxy)phenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

trifluoromethanesulfonic acid 1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl ester (1620885-37-1) + C19H17BrF3N3O2 (1620885-22-4) → 7’-bromo-1-(1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl)-3’-(4-(trifluoromethoxy)phenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one (1620884-97-0)

Guidance literature:

With p-toluenesulfonic acid monohydrate; In toluene; at 140 ℃; for 2h;

Reference yield:

1-(3,4-difluorophenyl)-2,2,2-trifluoroethanol (945978-37-0) → 7’-bromo-1-(1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl)-3’-(4-(trifluoromethoxy)phenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one (1620884-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine / cyclohexane / 2 h / -10 - 10 °C / Inert atmosphere

2: p-toluenesulfonic acid monohydrate / toluene / 2 h / 140 °C

With 2,6-dimethylpyridine; p-toluenesulfonic acid monohydrate; In cyclohexane; toluene;

Reference yield:

1-(3,4-difluorophenyl)-2,2,2-trifluoroethanone (302912-28-3) → 7’-bromo-1-(1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl)-3’-(4-(trifluoromethoxy)phenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one (1620884-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate; methanol / 1 h / 20 °C

2: 2,6-dimethylpyridine / cyclohexane / 2 h / -10 - 10 °C / Inert atmosphere

3: p-toluenesulfonic acid monohydrate / toluene / 2 h / 140 °C

With 2,6-dimethylpyridine; methanol; sodium tetrahydroborate; p-toluenesulfonic acid monohydrate; In cyclohexane; toluene;

upstream raw materials:

1-(3,4-difluorophenyl)-2,2,2-trifluoroethanol

1-(3,4-difluorophenyl)-2,2,2-trifluoroethanone

trifluoromethanesulfonic acid 1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl ester

C₁₉H₁₇BrF₃N₃O₂