S-ethyl (S)-5-(N-benzyloxycarbonyl-N-tert-butoxycarbonyl)amino-2-(tert-butoxycarbonyl)aminopentanethioate

Base Information

Chemical Name:S-ethyl (S)-5-(N-benzyloxycarbonyl-N-tert-butoxycarbonyl)amino-2-(tert-butoxycarbonyl)aminopentanethioate
CAS No.:886230-81-5
Molecular Formula:C₂₅H₃₈N₂O₇S
Molecular Weight:510.652
Hs Code.:

Synonyms:S-ethyl (S)-5-(N-benzyloxycarbonyl-N-tert-butoxycarbonyl)amino-2-(tert-butoxycarbonyl)aminopentanethioate

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Chemical Property of S-ethyl (S)-5-(N-benzyloxycarbonyl-N-tert-butoxycarbonyl)amino-2-(tert-butoxycarbonyl)aminopentanethioate

Chemical Property:

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Technology Process of S-ethyl (S)-5-(N-benzyloxycarbonyl-N-tert-butoxycarbonyl)amino-2-(tert-butoxycarbonyl)aminopentanethioate

There total 2 articles about S-ethyl (S)-5-(N-benzyloxycarbonyl-N-tert-butoxycarbonyl)amino-2-(tert-butoxycarbonyl)aminopentanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 459142-83-7
S-ethyl (S)-5-(benzyloxycarbonyl)amino-2-(tert-butoxycarbonyl)aminopentanethioate

: 886230-81-5
S-ethyl (S)-5-(N-benzyloxycarbonyl-N-tert-butoxycarbonyl)amino-2-(tert-butoxycarbonyl)aminopentanethioate

: C₃₀H₄₆N₂O₉S

Guidance literature:: With dmap; triethylamine; In acetonitrile; at 20 ℃;
DOI:10.1021/jo052676o

Reference yield:

: 2480-93-5
Boc-Orn(Z)-OH

: 886230-81-5
S-ethyl (S)-5-(N-benzyloxycarbonyl-N-tert-butoxycarbonyl)amino-2-(tert-butoxycarbonyl)aminopentanethioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: i-butylchloroformate; triethylamine / CH₂Cl₂ / 0.08 h / 0 °C

1.2: 100 percent / triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

2.1: 68 percent / triethylamine; DMAP / acetonitrile / 20 °C

With dmap; triethylamine; isobutyl chloroformate; In dichloromethane; acetonitrile;
DOI:10.1021/jo052676o

Reference yield:

: 886230-81-5
S-ethyl (S)-5-(N-benzyloxycarbonyl-N-tert-butoxycarbonyl)amino-2-(tert-butoxycarbonyl)aminopentanethioate

: 886230-80-4
C₂₃H₃₄N₂O₇

Guidance literature:: With triethylsilane; magnesium sulfate; palladium on activated charcoal; In acetone; at 20 ℃; for 1h;
DOI:10.1021/jo052676o