3-{4-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]-1-piperidinyl}propanoic acid

Base Information

Chemical Name:3-{4-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]-1-piperidinyl}propanoic acid
CAS No.:1344997-19-8
Molecular Formula:C₂₇H₃₂ClN₃O₃S
Molecular Weight:514.088
Hs Code.:

Synonyms:3-{4-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]-1-piperidinyl}propanoic acid

Suppliers and Price of 3-{4-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]-1-piperidinyl}propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-{4-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]-1-piperidinyl}propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{4-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]-1-piperidinyl}propanoic acid

There total 11 articles about 3-{4-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]-1-piperidinyl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260023-56-0
3-bromo-5-(3-chloro-4-isopropoxyphenyl)-1,2,4-thiadiazole

: 1344998-05-5
ethyl 3-{4-[2-ethyl-3-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-piperidinyl}propanoate

: 1344997-19-8
3-{4-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]-1-piperidinyl}propanoic acid

Guidance literature:: 3-bromo-5-(3-chloro-4-isopropoxyphenyl)-1,2,4-thiadiazole; ethyl 3-{4-[2-ethyl-3-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-piperidinyl}propanoate; With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 120 ℃; for 0.333333h; Biotage Initiator; Sealed; Inert atmosphere;

With water; sodium hydroxide; In isopropyl alcohol; at 50 ℃; for 2h;

With acetic acid; In isopropyl alcohol;

Reference yield:

: C₂₉H₃₆ClN₃O₃S

: 1344997-19-8
3-{4-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]-1-piperidinyl}propanoic acid

Guidance literature:: C₂₉H₃₆ClN₃O₃S; With water; sodium hydroxide; In isopropyl alcohol; at 50 ℃; for 2h;

With acetic acid; In water; isopropyl alcohol;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1344997-19-8
3-{4-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]-1-piperidinyl}propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

2: hydrogenchloride; acetic acid / water / 12 h / Reflux

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 90 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / ethyl acetate / 12 h / 50 °C / 2844.39 Torr

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 2 h / 80 °C / Sealed vessel

6: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.33 h / 120 °C / Sealed vessel; Inert atmosphere; Microwave irradiation

7: sodium hydroxide; water / isopropyl alcohol / 2 h / 50 °C

With hydrogenchloride; potassium phosphate; n-butyllithium; water; hydrogen; potassium acetate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; hexane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; 6: Suzuki Coupling;