2',3'-dideoxy-3'-C-(methoxytrityl)oxymethyl-α-L-threo-pentopyranosyl adenine

Base Information

Chemical Name:2',3'-dideoxy-3'-C-(methoxytrityl)oxymethyl-α-L-threo-pentopyranosyl adenine
CAS No.:173256-72-9
Molecular Formula:C₃₁H₃₁N₅O₄
Molecular Weight:537.618
Hs Code.:

Synonyms:2',3'-dideoxy-3'-C-(methoxytrityl)oxymethyl-α-L-threo-pentopyranosyl adenine

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Chemical Property of 2',3'-dideoxy-3'-C-(methoxytrityl)oxymethyl-α-L-threo-pentopyranosyl adenine

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Technology Process of 2',3'-dideoxy-3'-C-(methoxytrityl)oxymethyl-α-L-threo-pentopyranosyl adenine

There total 7 articles about 2',3'-dideoxy-3'-C-(methoxytrityl)oxymethyl-α-L-threo-pentopyranosyl adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 173256-64-9
4'-O-(2,4-dinitrobenzoyl)-2',3'-dideoxy-3'-C-(methoxytrityl)oxyphenyl-α-L-threo-pentoyranosyl adenine

: 173256-72-9
2',3'-dideoxy-3'-C-(methoxytrityl)oxymethyl-α-L-threo-pentopyranosyl adenine

Guidance literature:: With sodium methylate; In 1,4-dioxane; methanol;
DOI:10.1016/0040-4020(95)00777-6

Reference yield:

: 162934-32-9
(2',3'-Dideoxy-β-D-glycero-pent-2'-enopyranosyl)-N⁶-benzoyladenine

: 173256-72-9
2',3'-dideoxy-3'-C-(methoxytrityl)oxymethyl-α-L-threo-pentopyranosyl adenine

Guidance literature:: Multi-step reaction with 6 steps

1: imidazole / dimethylformamide / 1 h / Ambient temperature

2: tributyltin hydride, AIBN / toluene / 4 h / Heating

3: KF, 35 percent H₂O₂, KHCO₃ / dimethylformamide

4: 57 percent / pyridine, DMAP

5: 46 percent / triphenylphosphine, diethyl azodicarboxylate / dioxane / 4 h

6: 83 percent / sodium methoxide / methanol; dioxane

With pyridine; 1H-imidazole; dmap; potassium fluoride; 2,2'-azobis(isobutyronitrile); dihydrogen peroxide; tri-n-butyl-tin hydride; sodium methylate; potassium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4020(95)00777-6

Reference yield:

: 169514-16-3
N-{9-[(2R,5S)-5-(Bromomethyl-dimethyl-silanyloxy)-5,6-dihydro-2H-pyran-2-yl]-9H-purin-6-yl}-benzamide

: 173256-72-9
2',3'-dideoxy-3'-C-(methoxytrityl)oxymethyl-α-L-threo-pentopyranosyl adenine

Guidance literature:: Multi-step reaction with 5 steps

1: tributyltin hydride, AIBN / toluene / 4 h / Heating

2: KF, 35 percent H₂O₂, KHCO₃ / dimethylformamide

3: 57 percent / pyridine, DMAP

4: 46 percent / triphenylphosphine, diethyl azodicarboxylate / dioxane / 4 h

5: 83 percent / sodium methoxide / methanol; dioxane

With pyridine; dmap; potassium fluoride; 2,2'-azobis(isobutyronitrile); dihydrogen peroxide; tri-n-butyl-tin hydride; sodium methylate; potassium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4020(95)00777-6