4'-O-(2,4-dinitrobenzoyl)-2',3'-dideoxy-3'-C-(methoxytrityl)oxyphenyl-α-L-threo-pentoyranosyl adenine

Base Information

Chemical Name:4'-O-(2,4-dinitrobenzoyl)-2',3'-dideoxy-3'-C-(methoxytrityl)oxyphenyl-α-L-threo-pentoyranosyl adenine
CAS No.:173256-64-9
Molecular Formula:C₃₈H₃₃N₇O₉
Molecular Weight:731.722
Hs Code.:

Synonyms:4'-O-(2,4-dinitrobenzoyl)-2',3'-dideoxy-3'-C-(methoxytrityl)oxyphenyl-α-L-threo-pentoyranosyl adenine

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Chemical Property of 4'-O-(2,4-dinitrobenzoyl)-2',3'-dideoxy-3'-C-(methoxytrityl)oxyphenyl-α-L-threo-pentoyranosyl adenine

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Technology Process of 4'-O-(2,4-dinitrobenzoyl)-2',3'-dideoxy-3'-C-(methoxytrityl)oxyphenyl-α-L-threo-pentoyranosyl adenine

There total 7 articles about 4'-O-(2,4-dinitrobenzoyl)-2',3'-dideoxy-3'-C-(methoxytrityl)oxyphenyl-α-L-threo-pentoyranosyl adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 173256-63-8
2',3'-dideoxy-3'-C-(methoxytrityl)-oxymethyl-β-D-erythro-pentopyranosyl adenine

: 9-{(R)-4-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-3,6-dihydro-2H-pyran-2-yl}-9H-purin-6-ylamine

: 173256-64-9
4'-O-(2,4-dinitrobenzoyl)-2',3'-dideoxy-3'-C-(methoxytrityl)oxyphenyl-α-L-threo-pentoyranosyl adenine

Guidance literature:: With triphenylphosphine; 2,4-dinitrobenzoic acid; diethylazodicarboxylate; In 1,4-dioxane; for 4h;
DOI:10.1016/0040-4020(95)00777-6

Reference yield: 30.0%

: 610-30-0
2,4-dinitrobenzoic acid

: 173256-63-8
2',3'-dideoxy-3'-C-(methoxytrityl)-oxymethyl-β-D-erythro-pentopyranosyl adenine

: 9-{(R)-4-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-3,6-dihydro-2H-pyran-2-yl}-9H-purin-6-ylamine

: 173256-64-9
4'-O-(2,4-dinitrobenzoyl)-2',3'-dideoxy-3'-C-(methoxytrityl)oxyphenyl-α-L-threo-pentoyranosyl adenine

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; for 4h;
DOI:10.1016/0040-4020(95)00777-6

Reference yield:

: 162934-32-9
(2',3'-Dideoxy-β-D-glycero-pent-2'-enopyranosyl)-N⁶-benzoyladenine

: 173256-64-9
4'-O-(2,4-dinitrobenzoyl)-2',3'-dideoxy-3'-C-(methoxytrityl)oxyphenyl-α-L-threo-pentoyranosyl adenine

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole / dimethylformamide / 1 h / Ambient temperature

2: tributyltin hydride, AIBN / toluene / 4 h / Heating

3: KF, 35 percent H₂O₂, KHCO₃ / dimethylformamide

4: 57 percent / pyridine, DMAP

5: 46 percent / triphenylphosphine, diethyl azodicarboxylate / dioxane / 4 h

With pyridine; 1H-imidazole; dmap; potassium fluoride; 2,2'-azobis(isobutyronitrile); dihydrogen peroxide; tri-n-butyl-tin hydride; potassium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4020(95)00777-6