(5Z,7E)-(1S,3R)-3-(tert-butyldimethylsiloxy)-1,25-dihydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl acetate

Base Information

Chemical Name:(5Z,7E)-(1S,3R)-3-(tert-butyldimethylsiloxy)-1,25-dihydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl acetate
CAS No.:151922-34-8
Molecular Formula:C₃₅H₆₀O₅Si
Molecular Weight:588.944
Hs Code.:

Synonyms:(5Z,7E)-(1S,3R)-3-(tert-butyldimethylsiloxy)-1,25-dihydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl acetate

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Chemical Property of (5Z,7E)-(1S,3R)-3-(tert-butyldimethylsiloxy)-1,25-dihydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl acetate

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Technology Process of (5Z,7E)-(1S,3R)-3-(tert-butyldimethylsiloxy)-1,25-dihydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl acetate

There total 5 articles about (5Z,7E)-(1S,3R)-3-(tert-butyldimethylsiloxy)-1,25-dihydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 151922-34-8
(5Z,7E)-(1S,3R)-3-(tert-butyldimethylsiloxy)-1,25-dihydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature

2: 81 percent / pyridine / 3.5 h / Ambient temperature

3: 1.) Et₂O, irradiation, 2.) hexane, THF, room temperature, 14 days

With pyridine; 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1039/P19940001809

Reference yield:

: 151922-31-5
1α,2α-epoxy-cholesta-5,7-diene-3β,11α,25-triol

: 151922-34-8
(5Z,7E)-(1S,3R)-3-(tert-butyldimethylsiloxy)-1,25-dihydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / NaBH₄ / bis-(2-methoxy-ethyl) ether / 1 h / 80 °C

2: 91 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature

3: 81 percent / pyridine / 3.5 h / Ambient temperature

4: 1.) Et₂O, irradiation, 2.) hexane, THF, room temperature, 14 days

With pyridine; 1H-imidazole; sodium tetrahydroborate; In diethylene glycol dimethyl ether; N,N-dimethyl-formamide;
DOI:10.1039/P19940001809

Reference yield:

: 159352-61-1
1α,2α-epoxy-3β,11α,25-trihydroxy-4'-phenyl-3',5'-dihydro-5,8-<1,2>epi<1,2,4>triazolo-5α,8α-cholest-6-ene-3',5'-dione

: 151922-34-8
(5Z,7E)-(1S,3R)-3-(tert-butyldimethylsiloxy)-1,25-dihydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 1,1,3,3-tetramethylguanidine / 0.83 h / 170 °C

2: 70 percent / NaBH₄ / bis-(2-methoxy-ethyl) ether / 1 h / 80 °C

3: 91 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature

4: 81 percent / pyridine / 3.5 h / Ambient temperature

5: 1.) Et₂O, irradiation, 2.) hexane, THF, room temperature, 14 days

With pyridine; 1H-imidazole; sodium tetrahydroborate; N,N,N',N'-tetramethylguanidine; In diethylene glycol dimethyl ether; N,N-dimethyl-formamide;
DOI:10.1039/P19940001809