1,3-Bis(4-hydroxyphenyl)-2-propanol

Base Information

• Chemical Name: 1,3-Bis(4-hydroxyphenyl)-2-propanol
• CAS No.: 91793-46-3
• Molecular Formula: C₁₅H₁₆O₃
• Molecular Weight: 244.29
• Mol file: 91793-46-3.mol

Synonyms:1,3-Bis(4-hydroxyphenyl)propan-2-ol;Propterol;4,4'-(2-hydroxypropane-1,3-diyl)diphenol;4-(2-Hydroxy-3-(4-hydroxyphenyl)propyl)phenol;2-Propanol,1,3-bis(4-hydroxyphenyl);

Chemical Property of 1,3-Bis(4-hydroxyphenyl)-2-propanol

Chemical Property:

• Boiling Point: 458.8°Cat760mmHg
• Flash Point: 223.2°C
• PSA: 60.69000
• Density: 1.257g/cm³
• LogP: 2.24390

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Bis(4-hydroxyphenyl)-2-propanol

There total 4 articles about 1,3-Bis(4-hydroxyphenyl)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

1,3-bis(4-methoxyphenyl)-propan-2-ol (34414-51-2) → propterol A (91793-46-3)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.joc.9b02064

Reference yield:

1,3-bis(4-methoxyphenyl)acetone (29903-09-1) → propterol A (91793-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 12 h / 0 - 40 °C / Inert atmosphere

2: boron tribromide / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; boron tribromide; In methanol; dichloromethane;

DOI:10.1021/acs.joc.9b02064

Reference yield:

(E/Z)-1-methoxy-4-(2-methoxyvinyl)benzene (101565-19-9) → propterol A (91793-46-3)

Guidance literature:

Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate / 1,2-dichloro-ethane / 50 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 12 h / 0 - 40 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; boron trifluoride diethyl etherate; boron tribromide; In methanol; dichloromethane; 1,2-dichloro-ethane; 1: |Wagner-Meerwein Rearrangement;

DOI:10.1021/acs.joc.9b02064

upstream raw materials:

1,3-bis(4-methoxyphenyl)acetone

(E/Z)-1-methoxy-4-(2-methoxyvinyl)benzene

1,3-bis(4-methoxyphenyl)-propan-2-ol

4-Methoxybenzyl alcohol

Downstream raw materials:

1,3-bis(4-methoxyphenyl)-propan-2-ol

1,3-bis(4-methoxyphenyl)acetone