5-benzyloxy-3,3-dimethylpentanenitrile

Base Information

Chemical Name:5-benzyloxy-3,3-dimethylpentanenitrile
CAS No.:187663-94-1
Molecular Formula:C₁₄H₁₉NO
Molecular Weight:217.311
Hs Code.:

Synonyms:5-benzyloxy-3,3-dimethylpentanenitrile

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Chemical Property of 5-benzyloxy-3,3-dimethylpentanenitrile

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Technology Process of 5-benzyloxy-3,3-dimethylpentanenitrile

There total 5 articles about 5-benzyloxy-3,3-dimethylpentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 2-((benzyloxy)methyl)-3,3-dimethylcyclobutan-1-one O-benzoyl oxime

: 187663-94-1
5-benzyloxy-3,3-dimethylpentanenitrile

Guidance literature:: With 9,10-dihydroanthracene; potassium carbonate; bis(1,5-cyclooctadiene)diiridium(I) dichloride; In N,N-dimethyl-formamide; at 80 ℃; for 10h;
DOI:10.1021/ol0507120

Reference yield:

: 139108-26-2
5-Benzyloxy-3,3-dimethyl-pentanal

: 187663-94-1
5-benzyloxy-3,3-dimethylpentanenitrile

Guidance literature:: With Phenyl glycidyl ether; N,N-Dimethylhydrazine; In isopropyl alcohol; for 3h; Ambient temperature;
DOI:10.1021/jo961780q

Reference yield:

: 4160-82-1
3,3-dimethylglutaric anhydride

: 187663-94-1
5-benzyloxy-3,3-dimethylpentanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / tetrahydrofuran / 0 deg C to rt

2: 2.6 g / NaH / tetrahydrofuran / 0 °C

3: 1.) DMSO, oxalyl chloride, 2.) Et₃N / CH₂Cl₂ / 1.) -78 deg C, 1 h, 2.) -78 deg C to rt

4: 1.2 g / 1,2-epoxy-3-phenoxypropane, N,N-dimethylhydrazine / propan-2-ol / 3 h / Ambient temperature

With lithium aluminium tetrahydride; oxalyl dichloride; Phenyl glycidyl ether; sodium hydride; dimethyl sulfoxide; N,N-Dimethylhydrazine; triethylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1021/jo961780q