Technology Process of 4,4-dimethyl-3-methyl-6-(phenylmethoxy)-2-hexanone
There total 6 articles about 4,4-dimethyl-3-methyl-6-(phenylmethoxy)-2-hexanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(I) bromide;
In
tetrahydrofuran; diethyl ether;
at 80 ℃;
for 24h;
DOI:10.1021/jo961780q
- Guidance literature:
-
Multi-step reaction with 6 steps
1: LiAlH4 / tetrahydrofuran / 0 deg C to rt
2: 2.6 g / NaH / tetrahydrofuran / 0 °C
3: 1.) DMSO, oxalyl chloride, 2.) Et3N / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) -78 deg C to rt
4: 1.2 g / 1,2-epoxy-3-phenoxypropane, N,N-dimethylhydrazine / propan-2-ol / 3 h / Ambient temperature
5: 84 percent / LDA / tetrahydrofuran; hexane / -78 deg C, 1 h, rt, 1 h
6: 76 percent / CuBr / diethyl ether; tetrahydrofuran / 24 h / 80 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; Phenyl glycidyl ether; sodium hydride; dimethyl sulfoxide; N,N-Dimethylhydrazine; triethylamine; copper(I) bromide; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1021/jo961780q
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) DMSO, oxalyl chloride, 2.) Et3N / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) -78 deg C to rt
2: 1.2 g / 1,2-epoxy-3-phenoxypropane, N,N-dimethylhydrazine / propan-2-ol / 3 h / Ambient temperature
3: 84 percent / LDA / tetrahydrofuran; hexane / -78 deg C, 1 h, rt, 1 h
4: 76 percent / CuBr / diethyl ether; tetrahydrofuran / 24 h / 80 °C
With
oxalyl dichloride; Phenyl glycidyl ether; dimethyl sulfoxide; N,N-Dimethylhydrazine; triethylamine; copper(I) bromide; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; isopropyl alcohol;
DOI:10.1021/jo961780q
