(3S,4S)-4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazolidine-1,1-dioxide

Base Information

Chemical Name:(3S,4S)-4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazolidine-1,1-dioxide
CAS No.:1421479-35-7
Molecular Formula:C₁₂H₁₈N₂O₃S
Molecular Weight:270.353
Hs Code.:

Synonyms:(3S,4S)-4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazolidine-1,1-dioxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4S)-4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazolidine-1,1-dioxide

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Technology Process of (3S,4S)-4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazolidine-1,1-dioxide

There total 5 articles about (3S,4S)-4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazolidine-1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1421479-29-9
(3R,4S)-4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazolidine-1,1-dioxide

: 1421479-35-7
(3S,4S)-4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazolidine-1,1-dioxide

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ol3034753

Reference yield:

: 1421479-21-1
(S)-4-isopropyl-3-(4-methoxyphenyl)-4,5-dihydro-1,2,5-thiadiazoline-1,1-dioxide

: 1421479-35-7
(3S,4S)-4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazolidine-1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium borohydride / diethyl ether; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / 4 h / 20 °C / Inert atmosphere

With lithium borohydride; trifluoroacetic acid; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol3034753

Reference yield:

: 1421479-11-9
4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazole-1,1-dioxide

: 1421479-35-7
(3S,4S)-4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazolidine-1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); formic acid / acetonitrile / 48 h / -15 °C / Inert atmosphere

2: lithium borohydride / diethyl ether; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: trifluoroacetic acid / 4 h / 20 °C / Inert atmosphere

With lithium borohydride; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); formic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1021/ol3034753