(S)-2-(2-(4-azidobenzamido)acetamido)-3-((4-hydroxyphenethyl)amino)-3-oxopropyl dihydrogen phosphate

Base Information

Chemical Name:(S)-2-(2-(4-azidobenzamido)acetamido)-3-((4-hydroxyphenethyl)amino)-3-oxopropyl dihydrogen phosphate
CAS No.:1254200-46-8
Molecular Formula:C₂₀H₂₃N₆O₈P
Molecular Weight:506.412
Hs Code.:

Synonyms:(S)-2-(2-(4-azidobenzamido)acetamido)-3-((4-hydroxyphenethyl)amino)-3-oxopropyl dihydrogen phosphate

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Chemical Property of (S)-2-(2-(4-azidobenzamido)acetamido)-3-((4-hydroxyphenethyl)amino)-3-oxopropyl dihydrogen phosphate

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Technology Process of (S)-2-(2-(4-azidobenzamido)acetamido)-3-((4-hydroxyphenethyl)amino)-3-oxopropyl dihydrogen phosphate

There total 9 articles about (S)-2-(2-(4-azidobenzamido)acetamido)-3-((4-hydroxyphenethyl)amino)-3-oxopropyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: C₂₄H₃₃N₈O₆P

: 1254200-46-8
(S)-2-(2-(4-azidobenzamido)acetamido)-3-((4-hydroxyphenethyl)amino)-3-oxopropyl dihydrogen phosphate

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 9h; Inert atmosphere;
DOI:10.1002/cmdc.202000034

Reference yield:

: tert-butyl (S)-(3-(benzyloxy)-1-((4-hydroxyphenethyl)amino)-1-oxopropan-2-yl)carbamate

: 1254200-46-8
(S)-2-(2-(4-azidobenzamido)acetamido)-3-((4-hydroxyphenethyl)amino)-3-oxopropyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; ethanol / 20 °C

3.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

4.1: pyridine; tert-butylmagnesium chloride / acetonitrile / 24 h / 20 °C / Inert atmosphere

5.1: water; hydrogenchloride / 1,4-dioxane / 9 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; palladium 10% on activated carbon; tert-butylmagnesium chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen; triethylamine; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/cmdc.202000034

Reference yield:

: 6427-66-3
4-azidobenzoic acid

: 1254200-46-8
(S)-2-(2-(4-azidobenzamido)acetamido)-3-((4-hydroxyphenethyl)amino)-3-oxopropyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

4.1: pyridine; tert-butylmagnesium chloride / acetonitrile / 24 h / 20 °C / Inert atmosphere

5.1: water; hydrogenchloride / 1,4-dioxane / 9 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; tert-butylmagnesium chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/cmdc.202000034