1-methyl-1H-indole-2-carboxylic acid [3-(4-acetyl-phenyl)-prop-2-ynyl]-methyl-amide

Base Information

• Chemical Name: 1-methyl-1H-indole-2-carboxylic acid [3-(4-acetyl-phenyl)-prop-2-ynyl]-methyl-amide
• CAS No.: 1273578-18-9
• Molecular Formula: C₂₂H₂₀N₂O₂
• Molecular Weight: 344.413

Synonyms:1-methyl-1H-indole-2-carboxylic acid [3-(4-acetyl-phenyl)-prop-2-ynyl]-methyl-amide

Chemical Property of 1-methyl-1H-indole-2-carboxylic acid [3-(4-acetyl-phenyl)-prop-2-ynyl]-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-1H-indole-2-carboxylic acid [3-(4-acetyl-phenyl)-prop-2-ynyl]-methyl-amide

There total 2 articles about 1-methyl-1H-indole-2-carboxylic acid [3-(4-acetyl-phenyl)-prop-2-ynyl]-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-methyl-1H-indole-2-carboxylic acid methyl-prop-2-ynyl-amide (906543-07-5) + 4-Iodoacetophenone (13329-40-3) → 1-methyl-1H-indole-2-carboxylic acid [3-(4-acetyl-phenyl)-prop-2-ynyl]-methyl-amide (1273578-18-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; for 20h; Inert atmosphere; Sealed tube; Heating;

DOI:10.1039/c0ob00728e

Reference yield:

N-methyl-1H-indole-2-carboxylic acid (16136-58-6) → 1-methyl-1H-indole-2-carboxylic acid [3-(4-acetyl-phenyl)-prop-2-ynyl]-methyl-amide (1273578-18-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

1.2: 40 °C / Inert atmosphere

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 20 h / Inert atmosphere; Sealed tube; Heating

With dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 2.1: Sonogashira reaction;

DOI:10.1039/c0ob00728e

Reference yield: 21.0%

1-methyl-1H-indole-2-carboxylic acid [3-(4-acetyl-phenyl)-prop-2-ynyl]-methyl-amide (1273578-18-9) → 5-(4-acetylphenyl)-2,10-dimethyl-3,10-dihydro-2H-azepino[3,4-b]indol-1-one (1273578-31-6) + 4-(4-acetylbenzyl)-2,9-dimethyl-2,9-dihydro-β-carbolin-1-one (1273578-45-2)

Guidance literature:

With platinum(II) chloride; In dichloromethane; at 50 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1039/c0ob00728e

upstream raw materials:

1-methyl-1H-indole-2-carboxylic acid methyl-prop-2-ynyl-amide

4-Iodoacetophenone

N-methyl-1H-indole-2-carboxylic acid

Downstream raw materials:

5-(4-acetylphenyl)-2,10-dimethyl-3,10-dihydro-2H-azepino[3,4-b]indol-1-one

4-(4-acetylbenzyl)-2,9-dimethyl-2,9-dihydro-β-carbolin-1-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1273578-18-9 1-methyl-1H-indole-2-carboxylic acid [3-(4-acetyl-phenyl)-prop-2-ynyl]-methyl-amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send