18-acetoxyvitamin D₃

Base Information

Chemical Name:18-acetoxyvitamin D₃
CAS No.:140927-91-9
Molecular Formula:C₂₉H₄₆O₃
Molecular Weight:442.682
Hs Code.:

Synonyms:18-acetoxyvitamin D₃

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Chemical Property of 18-acetoxyvitamin D₃

Chemical Property:

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Technology Process of 18-acetoxyvitamin D₃

There total 7 articles about 18-acetoxyvitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 140928-01-4
18-acetoxyvitamin D₃ tert-butyldimethylsilyl ether

: 140927-91-9
18-acetoxyvitamin D₃

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 12h; Ambient temperature;
DOI:10.1021/jo00037a046

Reference yield:

: 33813-99-9
Grundmann's alcohol

: 140927-91-9
18-acetoxyvitamin D₃

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / Pb(OAc)4, pyridine / benzene / 2.5 h / Ambient temperature; Irradiation

2: 1.) BF₃*Et₂O / 1.) ether, -20 deg C, 0.5 h, 2.) r. t., 0.5 h

3: 73 percent / K₂CO₃ / methanol / 1 h / Ambient temperature

4: 87 percent / pyridinium dichromate (PDC), pyridinium trifluoroacetate (PTFA) / CH₂Cl₂ / 4 h

5: 1.) n-BuLi / 1.) hexanes, THF, -78 deg C, 10 min, 2.) THF, -78 deg C, 2 h

6: 83 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 12 h / Ambient temperature

With pyridine; lead(IV) acetate; dipyridinium dichromate; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridinium trifluroacetate; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/jo00037a046

Reference yield:

: 66251-18-1
Grundmann's ketone

: 140927-91-9
18-acetoxyvitamin D₃

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / LiAlH₄ / diethyl ether

2: 91 percent / Pb(OAc)4, pyridine / benzene / 2.5 h / Ambient temperature; Irradiation

3: 1.) BF₃*Et₂O / 1.) ether, -20 deg C, 0.5 h, 2.) r. t., 0.5 h

4: 73 percent / K₂CO₃ / methanol / 1 h / Ambient temperature

5: 87 percent / pyridinium dichromate (PDC), pyridinium trifluoroacetate (PTFA) / CH₂Cl₂ / 4 h

6: 1.) n-BuLi / 1.) hexanes, THF, -78 deg C, 10 min, 2.) THF, -78 deg C, 2 h

7: 83 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 12 h / Ambient temperature

With pyridine; lead(IV) acetate; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridinium trifluroacetate; potassium carbonate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1021/jo00037a046