2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarboxamide

Base Information

Chemical Name:2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarboxamide
CAS No.:1346226-56-9
Molecular Formula:C₁₉H₁₅F₃N₄O₃
Molecular Weight:404.348
Hs Code.:

Synonyms:2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarboxamide

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Chemical Property of 2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarboxamide

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Technology Process of 2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarboxamide

There total 4 articles about 2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 873942-91-7
4-hydroxy-8-(trifluoromethyl)quinoline-3-carbohydrazide

: 622-58-2,374675-64-6
p-Tolylisocyanate

: 1346226-56-9
2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarboxamide

Guidance literature:: With pyridine; In ethanol; for 1h; Reflux;
DOI:10.1016/j.ejmech.2011.07.033

Reference yield:

: 23779-94-4
2-[(2-trifluoromethylphenylamino)methylene]malonic acid diethyl ester

: 1346226-56-9
2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: Dowtherm medium / 4 h / 250 °C

2: hydrazine hydrate / ethanol / 2.5 h / Reflux

3: pyridine / ethanol / 1 h / Reflux

With pyridine; hydrazine hydrate; In ethanol; Dowtherm medium;
DOI:10.1016/j.ejmech.2011.07.033

Reference yield:

: 88-17-5
2-(trifluoromethyl)benzenamine

: 1346226-56-9
2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 4 h / 110 °C

2: Dowtherm medium / 4 h / 250 °C

3: hydrazine hydrate / ethanol / 2.5 h / Reflux

4: pyridine / ethanol / 1 h / Reflux

With pyridine; hydrazine hydrate; In ethanol; Dowtherm medium;
DOI:10.1016/j.ejmech.2011.07.033