873942-91-7

Basic information

• Product Name: 4-hydroxy-8-(trifluoromethyl)quinoline-3-carbohydrazide
• Synonyms: 4-hydroxy-8-(trifluoromethyl)quinoline-3-carbohydrazide
• CAS NO: 873942-91-7
• Molecular Weight: 271.199
• Mol File: 873942-91-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-hydroxy-8-(trifluoromethyl)quinoline-3-carbohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-8-(trifluoromethyl)quinoline-3-carbohydrazide(873942-91-7)
• EPA Substance Registry System: 4-hydroxy-8-(trifluoromethyl)quinoline-3-carbohydrazide(873942-91-7)

Safety Data

• Hazardous Substances Data: 873942-91-7(Hazardous Substances Data)

Upstream product

• 23779-95-5 4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylic acid 
• 23851-84-5 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 23779-94-4 2-[(2-trifluoromethylphenylamino)methylene]malonic acid diethyl ester 

Downstream Products

• 1198229-59-2 C₁₉H₁₅F₃N₄O₂S 
• 1198229-60-5 C₁₈H₁₃F₃N₄O₂S 
• 1346226-45-6 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid (3-hydroxy-4-methoxy-benzylidene)-hydrazide 
• 1346226-43-4 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid (5-fluoro-2-hydroxy-benzylidene)-hydrazide 
• 1346226-42-3 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid (2-methylsulfanyl-benzylidene)-hydrazide 
• 1346226-41-2 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid [4-(1,1,2,2-tetrafluoro-ethoxy)-benzylidene]-hydrazide 
• 1346226-40-1 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid (2-fluoro-4-methoxy-benzylidene)-hydrazide 
• 1346226-50-3 N-(2-fluorophenyl)-2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}hydrazinecarbothioamide 
• 1346226-44-5 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid (4-methoxy-benzylidene)-hydrazide 
• 1346226-56-9 2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarboxamide 
• 1346226-55-8 2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methoxyphenyl)hydrazinecarboxamide 
• 1346226-52-5 2-{[4-hydroxy-8-(trifluoromethyl)quinoline-3-yl]carbonyl}-N-(4-methoxyphenyl)hydrazinecarbothioamide 
• 1346226-49-0 N-(3-chlorophenyl)-2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}hydrazinecarbothioamide 
• 1346226-51-4 2-{[4-hydroxy-8-(trifluoromethyl)quinolin-3-yl]carbonyl}-N-(4-methylphenyl)hydrazinecarbothioamide 

Relevant articles and documents

Synthesis, identification and in vitro biological evaluation of some novel quinoline incorporated 1,3-thiazinan-4-one derivatives

The present study describes the synthesis of two new series of 3-hydroxy-N-(4-oxo-2-phenyl-1,3-thiazinan-3-yl)-8-(trifluoromethyl)quinoline-2-carboxamide derivatives (4a–j) and 3-((7-chloroquinolin-4-ylamino)methyl)-2-phenyl-1,3-thiazinan-4-one derivatives (5a–7j). All the compounds were synthesized in moderate to good yield by one-pot three component cyclo-condensation reaction. The newly synthesized compounds were characterized by FT-IR,1H,13C NMR and elemental analysis. The compounds were screened for their in vitro antibacterial activity against a panel of pathogenic bacterial strains, antitubercular activity against Mycobacterium tuberculosis H37Rv and also for their in vitro antimalarial activity against Plasmodium falciparum. Among the synthesized compounds two of them (4f and 5f) showed excellent antibacterial activity against C. tetani at 15.6?μg/mL. Some of them exhibited excellent antitubercular (4f & 5f) and good antimalarial (4f, 5f & 6f) activity compared with the first line drugs.

Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents

Three new series of 4-hydroxy-8-trifluoromethyl-quinoline derivatives were synthesized through multi step reactions. All the newly synthesized compounds were characterized by spectral and elemental analyses. The structure of 5j was evidenced by X-ray crystallographic study. The newly synthesized title compounds were evaluated for their antimicrobial activities including antimycobacterial activity. Amongst the tested compounds, 5b, 5e, 5h, 5j, 6c and 7c displayed promising antimicrobial activity. The mode of action of these active compounds was carried out by docking of receptor enoyl-ACP reductase with newly synthesized candidate ligands, 5b, 5e, 5h, 5j and 6c.