(1-tert-butoxycarbonyl-L-prolyl)-N¹-((2S)-1-{4-[4-(3,28-dioxolup-20⁽²⁹⁾-en-28-ylamino)phenyl]-1H-1,2,3-triazol-1-yl}3-phenylprop-2-yl)-N²-(4-methoxybenzyl)-2-methylalanineamide

Base Information

• Chemical Name: (1-tert-butoxycarbonyl-L-prolyl)-N¹-((2S)-1-{4-[4-(3,28-dioxolup-20⁽²⁹⁾-en-28-ylamino)phenyl]-1H-1,2,3-triazol-1-yl}3-phenylprop-2-yl)-N²-(4-methoxybenzyl)-2-methylalanineamide
• CAS No.: 1392483-51-0
• Molecular Formula: C₆₉H₉₃N₇O₇
• Molecular Weight: 1132.54

Synonyms:(1-tert-butoxycarbonyl-L-prolyl)-N¹-((2S)-1-{4-[4-(3,28-dioxolup-20⁽²⁹⁾-en-28-ylamino)phenyl]-1H-1,2,3-triazol-1-yl}3-phenylprop-2-yl)-N²-(4-methoxybenzyl)-2-methylalanineamide

Chemical Property of (1-tert-butoxycarbonyl-L-prolyl)-N¹-((2S)-1-{4-[4-(3,28-dioxolup-20⁽²⁹⁾-en-28-ylamino)phenyl]-1H-1,2,3-triazol-1-yl}3-phenylprop-2-yl)-N²-(4-methoxybenzyl)-2-methylalanineamide

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Technology Process of (1-tert-butoxycarbonyl-L-prolyl)-N¹-((2S)-1-{4-[4-(3,28-dioxolup-20⁽²⁹⁾-en-28-ylamino)phenyl]-1H-1,2,3-triazol-1-yl}3-phenylprop-2-yl)-N²-(4-methoxybenzyl)-2-methylalanineamide

There total 2 articles about (1-tert-butoxycarbonyl-L-prolyl)-N¹-((2S)-1-{4-[4-(3,28-dioxolup-20⁽²⁹⁾-en-28-ylamino)phenyl]-1H-1,2,3-triazol-1-yl}3-phenylprop-2-yl)-N²-(4-methoxybenzyl)-2-methylalanineamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

N-(3-oxo-20(29)-lupen-28-oyl)-4-ethynylaniline (1185845-52-6) + (1-tert-butoxycarbonyl-L-prolyl)-N1-[(2S)-1-azido-3-phenyl-prop-2-yl]-N2-(4-methoxybenzyl)-2-methylalanineamide (1352924-74-3) → (1-tert-butoxycarbonyl-L-prolyl)-N1-((2S)-1-{4-[4-(3,28-dioxolup-20(29)-en-28-ylamino)phenyl]-1H-1,2,3-triazol-1-yl}3-phenylprop-2-yl)-N2-(4-methoxybenzyl)-2-methylalanineamide (1392483-51-0)

Guidance literature:

With copper(l) chloride; In butan-1-ol; at 110 - 115 ℃;

DOI:10.1007/s11172-011-0369-3

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + 1-[(S)-3-azido-2-isocyanopropyl]benzene (1223635-87-7) + 4-methoxy-benzylamine (2393-23-9) → (1-tert-butoxycarbonyl-L-prolyl)-N1-((2S)-1-{4-[4-(3,28-dioxolup-20(29)-en-28-ylamino)phenyl]-1H-1,2,3-triazol-1-yl}3-phenylprop-2-yl)-N2-(4-methoxybenzyl)-2-methylalanineamide (1392483-51-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 24 h / 20 °C

2: copper(l) chloride / butan-1-ol / 110 - 115 °C

With copper(l) chloride; In methanol; butan-1-ol;

DOI:10.1007/s11172-011-0369-3

upstream raw materials:

N-(3-oxo-20⁽²⁹⁾-lupen-28-oyl)-4-ethynylaniline

(1-tert-butoxycarbonyl-L-prolyl)-N¹-[(2S)-1-azido-3-phenyl-prop-2-yl]-N²-(4-methoxybenzyl)-2-methylalanineamide

1-(tert-butoxycarbonyl)-L-proline

1-[(S)-3-azido-2-isocyanopropyl]benzene

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