trans-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]-pyridin-4-yl)amino)cyclohexanecarbonitrile

Base Information

Chemical Name:trans-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]-pyridin-4-yl)amino)cyclohexanecarbonitrile
CAS No.:1315498-70-4
Molecular Formula:C₂₀H₁₉N₅O₄S
Molecular Weight:425.468
Hs Code.:

Synonyms:trans-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]-pyridin-4-yl)amino)cyclohexanecarbonitrile

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Chemical Property of trans-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]-pyridin-4-yl)amino)cyclohexanecarbonitrile

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Technology Process of trans-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]-pyridin-4-yl)amino)cyclohexanecarbonitrile

There total 1 articles about trans-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]-pyridin-4-yl)amino)cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1245649-52-8
1-(benzenesulfonyl)-4-chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine

: 1198163-55-1
trans-4-aminocyclohexanecarbonitrile trifluoroacetic acid salt

: 1315498-70-4
trans-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]-pyridin-4-yl)amino)cyclohexanecarbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; for 3h; Inert atmosphere; Reflux;
DOI:10.1021/jm4004895

Reference yield: 97.0%

: 1315498-70-4
trans-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]-pyridin-4-yl)amino)cyclohexanecarbonitrile

: 1315498-71-5
trans-4-((5-amino-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]-pyridin-4-yl)amino)cyclohexanecarbonitrile

Guidance literature:: With iron; ammonium chloride; In ethanol; water; for 4h; Inert atmosphere; Reflux;
DOI:10.1021/jm4004895

Reference yield:

: 1315498-70-4
trans-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]-pyridin-4-yl)amino)cyclohexanecarbonitrile

: 1315498-72-6
trans-4-(2-((R)-1-hydroxyethyl)-6-(phenylsulfonyl)imidazo-[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: iron; ammonium chloride / ethanol; water / 4 h / Inert atmosphere; Reflux

2.1: triethyloxonium tetrafluoroborate / tetrahydrofuran / 2 h / 23 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere; Reflux

With triethyloxonium tetrafluoroborate; iron; ammonium chloride; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm4004895