trans-4-(2-((R)-1-hydroxyethyl)-6-(phenylsulfonyl)imidazo-[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanecarbonitrile

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Chemical Name:trans-4-(2-((R)-1-hydroxyethyl)-6-(phenylsulfonyl)imidazo-[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanecarbonitrile
CAS No.:1315498-72-6
Molecular Formula:C₂₃H₂₃N₅O₃S
Molecular Weight:449.533
Hs Code.:

Synonyms:trans-4-(2-((R)-1-hydroxyethyl)-6-(phenylsulfonyl)imidazo-[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanecarbonitrile

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Chemical Property of trans-4-(2-((R)-1-hydroxyethyl)-6-(phenylsulfonyl)imidazo-[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanecarbonitrile

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Technology Process of trans-4-(2-((R)-1-hydroxyethyl)-6-(phenylsulfonyl)imidazo-[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanecarbonitrile

There total 4 articles about trans-4-(2-((R)-1-hydroxyethyl)-6-(phenylsulfonyl)imidazo-[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 598-81-2
(R)-lactamide

: 1315498-71-5
trans-4-((5-amino-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]-pyridin-4-yl)amino)cyclohexanecarbonitrile

: 1315498-72-6
trans-4-(2-((R)-1-hydroxyethyl)-6-(phenylsulfonyl)imidazo-[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanecarbonitrile

Guidance literature:: (R)-lactamide; With triethyloxonium tetrafluoroborate; In tetrahydrofuran; at 23 ℃; for 2h; Inert atmosphere;

trans-4-((5-amino-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]-pyridin-4-yl)amino)cyclohexanecarbonitrile; In ethanol; for 2h; Inert atmosphere; Reflux;
DOI:10.1021/jm4004895

Reference yield:

: 1198163-55-1
trans-4-aminocyclohexanecarbonitrile trifluoroacetic acid salt

: 1315498-72-6
trans-4-(2-((R)-1-hydroxyethyl)-6-(phenylsulfonyl)imidazo-[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3 h / Inert atmosphere; Reflux

2.1: iron; ammonium chloride / ethanol; water / 4 h / Inert atmosphere; Reflux

3.1: triethyloxonium tetrafluoroborate / tetrahydrofuran / 2 h / 23 °C / Inert atmosphere

3.2: 2 h / Inert atmosphere; Reflux

With triethyloxonium tetrafluoroborate; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; isopropyl alcohol;
DOI:10.1021/jm4004895

Reference yield:

: 1315498-70-4
trans-4-((5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]-pyridin-4-yl)amino)cyclohexanecarbonitrile

: 1315498-72-6
trans-4-(2-((R)-1-hydroxyethyl)-6-(phenylsulfonyl)imidazo-[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: iron; ammonium chloride / ethanol; water / 4 h / Inert atmosphere; Reflux

2.1: triethyloxonium tetrafluoroborate / tetrahydrofuran / 2 h / 23 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere; Reflux

With triethyloxonium tetrafluoroborate; iron; ammonium chloride; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm4004895