(R)-(9H-fluoren-9-yl)methyl 4-(azetidin-1-yl)-4-oxo-1-(phenylthio)butan-2-yl carbamate

Base Information

• Chemical Name: (R)-(9H-fluoren-9-yl)methyl 4-(azetidin-1-yl)-4-oxo-1-(phenylthio)butan-2-yl carbamate
• CAS No.: 1402141-81-4
• Molecular Formula: C₂₈H₂₈N₂O₃S
• Molecular Weight: 472.608
• Mol file: 1402141-81-4.mol

Synonyms:(R)-(9H-fluoren-9-yl)methyl 4-(azetidin-1-yl)-4-oxo-1-(phenylthio)butan-2-yl carbamate

Chemical Property of (R)-(9H-fluoren-9-yl)methyl 4-(azetidin-1-yl)-4-oxo-1-(phenylthio)butan-2-yl carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(9H-fluoren-9-yl)methyl 4-(azetidin-1-yl)-4-oxo-1-(phenylthio)butan-2-yl carbamate

There total 1 articles about (R)-(9H-fluoren-9-yl)methyl 4-(azetidin-1-yl)-4-oxo-1-(phenylthio)butan-2-yl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

azetidine (503-29-7) + (R)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(phenylthio)butanoic acid (1244724-97-7) → (R)-(9H-fluoren-9-yl)methyl 4-(azetidin-1-yl)-4-oxo-1-(phenylthio)butan-2-yl carbamate (1402141-81-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/jm3010306

Reference yield: 98.0%

(R)-(9H-fluoren-9-yl)methyl 4-(azetidin-1-yl)-4-oxo-1-(phenylthio)butan-2-yl carbamate (1402141-81-4) → (R)-3-amino-1-(azetidin-1-yl)-4-(phenylthio)butan-1-one (1402141-82-5)

Guidance literature:

With diethylamine; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1021/jm3010306

Reference yield:

(R)-(9H-fluoren-9-yl)methyl 4-(azetidin-1-yl)-4-oxo-1-(phenylthio)butan-2-yl carbamate (1402141-81-4) → (R)-4-(3-(4-(4-(4-(4-(azetidin-1-yl)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)-piperazin-1-yl)phenyl)-5-(4-chlorophenyl)-1,2-dimethyl-1H-pyrrole-3-carboxylic acid (1402141-62-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diethylamine / acetonitrile / 2 h / 20 °C

2.1: borane-THF / 16 h / 20 °C / Inert atmosphere

2.2: 3 h / 80 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With borane-THF; diethylamine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm3010306

upstream raw materials:

azetidine

(R)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(phenylthio)butanoic acid

Downstream raw materials:

(R)-4-(3-(4-(4-(4-(4-(azetidin-1-yl)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)-piperazin-1-yl)phenyl)-5-(4-chlorophenyl)-1,2-dimethyl-1H-pyrrole-3-carboxylic acid

(R)-4-(azetidin-1-yl)-1-(phenylthio)butan-2-amine

(R)-3-amino-1-(azetidin-1-yl)-4-(phenylthio)butan-1-one