7α-(Benzyloxy)-24ξ-<(tert-butyldimethylsilyl)oxy>cholest-3-one

Base Information

Chemical Name:7α-(Benzyloxy)-24ξ-<(tert-butyldimethylsilyl)oxy>cholest-3-one
CAS No.:186139-66-2
Molecular Formula:C₄₀H₆₆O₃Si
Molecular Weight:623.048
Hs Code.:

Synonyms:7α-(Benzyloxy)-24ξ-<(tert-butyldimethylsilyl)oxy>cholest-3-one

Suppliers and Price of 7α-(Benzyloxy)-24ξ-<(tert-butyldimethylsilyl)oxy>cholest-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7α-(Benzyloxy)-24ξ-<(tert-butyldimethylsilyl)oxy>cholest-3-one

Chemical Property:

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Technology Process of 7α-(Benzyloxy)-24ξ-<(tert-butyldimethylsilyl)oxy>cholest-3-one

There total 14 articles about 7α-(Benzyloxy)-24ξ-<(tert-butyldimethylsilyl)oxy>cholest-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.4%

: 186139-65-1
7α-(Benzyloxy)-24ξ-<(tert-butyldimethylsilyl)oxy>cholestan-3β-ol

: 186139-66-2
7α-(Benzyloxy)-24ξ-<(tert-butyldimethylsilyl)oxy>cholest-3-one

: 7α-(Benzoyloxy)-24ξ-<(tert-butyldimethylsilyl)oxy>cholest-3-one

Guidance literature:: With dipyridine chromium trioxide; In dichloromethane; Ambient temperature;
DOI:10.1021/jo00121a033

Reference yield:

: 5255-17-4
3β-hydroxy-5-cholenoic acid

: 186139-66-2
7α-(Benzyloxy)-24ξ-<(tert-butyldimethylsilyl)oxy>cholest-3-one

Guidance literature:: Multi-step reaction with 13 steps

1: 92 percent / PPTS / CH₂Cl₂ / Ambient temperature

2: 92 percent / LiAlH₄ / tetrahydrofuran / 0 °C

3: 98 percent / imidazole / CH₂Cl₂ / Ambient temperature

4: 59 percent / CrO₃, 3,5-dimethylpyrazole / CH₂Cl₂ / Ambient temperature

5: 71 percent / H₂ / PtO₂ / ethyl acetate / 2.5 h

6: 94 percent / K-Selectride / tetrahydrofuran / 5 h / 50 °C

7: 87 percent / NaH / dimethylformamide; tetrahydrofuran / 1.) overnight; 40 deg C, 20 min, 2.) 40 deg C, 10 h

8: 90 percent / TBAF / tetrahydrofuran

9: 1.) (COCl)2, DMSO, 2.) DIPEA / 1.) CH₂Cl₂, -78 deg C, 40 min, 2.) 0 deg C, 30 min

10: 77 percent / tetrahydrofuran / Ambient temperature

11: 96 percent / imidazole / CH₂Cl₂ / 24 h / Ambient temperature

12: 98 percent / MgBr₂ / diethyl ether

13: 87 percent / Collin's reagent / CH₂Cl₂ / Ambient temperature

With 1H-imidazole; 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; lithium aluminium tetrahydride; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; dipyridine chromium trioxide; sodium hydride; potassium tri-sec-butyl-borohydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; magnesium bromide; platinum(IV) oxide; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a033

Reference yield:

: 66414-43-5
3β-(tetrahydro-2H-pyran-2-yloxy)chol-5-en-24-ol

: 186139-66-2
7α-(Benzyloxy)-24ξ-<(tert-butyldimethylsilyl)oxy>cholest-3-one

Guidance literature:: Multi-step reaction with 11 steps

1: 98 percent / imidazole / CH₂Cl₂ / Ambient temperature

2: 59 percent / CrO₃, 3,5-dimethylpyrazole / CH₂Cl₂ / Ambient temperature

3: 71 percent / H₂ / PtO₂ / ethyl acetate / 2.5 h

4: 94 percent / K-Selectride / tetrahydrofuran / 5 h / 50 °C

5: 87 percent / NaH / dimethylformamide; tetrahydrofuran / 1.) overnight; 40 deg C, 20 min, 2.) 40 deg C, 10 h

6: 90 percent / TBAF / tetrahydrofuran

7: 1.) (COCl)2, DMSO, 2.) DIPEA / 1.) CH₂Cl₂, -78 deg C, 40 min, 2.) 0 deg C, 30 min

8: 77 percent / tetrahydrofuran / Ambient temperature

9: 96 percent / imidazole / CH₂Cl₂ / 24 h / Ambient temperature

10: 98 percent / MgBr₂ / diethyl ether

11: 87 percent / Collin's reagent / CH₂Cl₂ / Ambient temperature

With 1H-imidazole; 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; dipyridine chromium trioxide; sodium hydride; potassium tri-sec-butyl-borohydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; magnesium bromide; platinum(IV) oxide; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a033