(2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester
CAS No.:700875-91-8
Molecular Formula:C₁₈H₂₄N₂O₃
Molecular Weight:316.4
Hs Code.:

Synonyms:(2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester

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Technology Process of (2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester

There total 10 articles about (2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 95924-70-2
*,R^*)>-2-<<<1-(Hydroxymethyl)-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

: 700875-91-8
(2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With dmap; triethylamine; p-toluenesulfonyl chloride; In 1,2-dichloro-ethane; at 20 ℃; Reflux; Inert atmosphere;
DOI:10.1021/ol303465c

Reference yield: 85.0%

: 2026-48-4,473-75-6
(S)-valinol

: 63808-36-6
(2S)-2-cyanopyrrolidine-1-carboxylic acid benzyl ester

: 700875-91-8
(2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With zinc(II) chloride; In chlorobenzene; for 24h; Heating;
DOI:10.1139/V06-188

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 700875-91-8
(2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; iodine / tetrahydrofuran / Reflux; Inert atmosphere

2: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0 - 20 °C / Inert atmosphere

3: p-toluenesulfonyl chloride; dmap; triethylamine / 1,2-dichloro-ethane / 20 °C / Reflux; Inert atmosphere

With 4-methyl-morpholine; dmap; sodium tetrahydroborate; iodine; triethylamine; p-toluenesulfonyl chloride; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol303465c