2-(cyclohexanecarboxamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

Base Information

Chemical Name:2-(cyclohexanecarboxamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
CAS No.:524693-92-3
Molecular Formula:C₁₆H₂₃N₃O₂S
Molecular Weight:321.444
Hs Code.:

Synonyms:2-(cyclohexanecarboxamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

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Chemical Property of 2-(cyclohexanecarboxamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

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Technology Process of 2-(cyclohexanecarboxamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

There total 4 articles about 2-(cyclohexanecarboxamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1585245-08-4
C₁₅H₂₁N₃O₂S*C₂HF₃O₂

: 524693-92-3
2-(cyclohexanecarboxamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In methanol; water; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2014.02.028

Reference yield:

: 1001020-08-1
tert-butyl 2-amino-3-carbamoyl-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate

: 524693-92-3
2-(cyclohexanecarboxamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

2: dichloromethane / 2 h / 20 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride; acetic acid / methanol; water / 1 h / 20 °C

With sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2014.02.028

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 524693-92-3
2-(cyclohexanecarboxamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sulfur; morpholine / ethanol / 12 h / 20 °C

2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

3: dichloromethane / 2 h / 20 °C / Inert atmosphere

4: sodium tris(acetoxy)borohydride; acetic acid / methanol; water / 1 h / 20 °C

With morpholine; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; sulfur; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; ethanol; dichloromethane; water; 1: |Gewald Aminoheterocycles Synthesis;
DOI:10.1016/j.ejmech.2014.02.028