(S)-2-{(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-3-phenyl-propionic acid methyl ester

Base Information

• Chemical Name: (S)-2-{(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-3-phenyl-propionic acid methyl ester
• CAS No.: 122899-98-3
• Molecular Formula: C₃₆H₄₈N₃O₈P
• Molecular Weight: 681.766

Synonyms:(S)-2-{(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-3-phenyl-propionic acid methyl ester

Chemical Property of (S)-2-{(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-3-phenyl-propionic acid methyl ester

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Technology Process of (S)-2-{(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-3-phenyl-propionic acid methyl ester

There total 2 articles about (S)-2-{(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(Diethoxy-phosphorylamino)-4-methyl-pentanoic acid benzyl ester → (S)-2-{(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-3-phenyl-propionic acid methyl ester (122899-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 760 Torr

2: 1-hydroxybenzotriazole, DCC / dimethylformamide / 10 h / 4 °C

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00163a044

Reference yield:

N--L-leucine (122899-91-6) + H-Tyr(OBzl)-Phe-OMe (63779-73-7) → (S)-2-{(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-3-phenyl-propionic acid methyl ester (122899-98-3)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 4 ℃; for 10h;

DOI:10.1021/jm00163a044

Reference yield:

(S)-2-{(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-3-phenyl-propionic acid methyl ester (122899-98-3) → (S)-2-{(S)-3-(4-Benzyloxy-phenyl)-2-[(2S,3S)-2-(diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-3-phenyl-propionic acid

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr;

DOI:10.1021/jm00163a044

upstream raw materials:

N--L-leucine

H-Tyr(OBzl)-Phe-OMe

Downstream raw materials:

Potassium; (S)-2-{(S)-3-(4-benzyloxy-phenyl)-2-[(2S,3S)-2-(ethoxy-hydroxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-3-phenyl-propionate

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