3-<2,6-dimethoxy-4-(5'-((2)H3)pentyl)phenyl>-4-isopropenyl-1-(((trifluoromethyl)sulfonyl)oxy)cyclohex-1-ene

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Chemical Name:3-<2,6-dimethoxy-4-(5'-((2)H3)pentyl)phenyl>-4-isopropenyl-1-(((trifluoromethyl)sulfonyl)oxy)cyclohex-1-ene
CAS No.:145104-80-9
Molecular Formula:C₂₃H₃₁F₃O₅S
Molecular Weight:479.534
Hs Code.:

Synonyms:3-<2,6-dimethoxy-4-(5'-((2)H3)pentyl)phenyl>-4-isopropenyl-1-(((trifluoromethyl)sulfonyl)oxy)cyclohex-1-ene

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Chemical Property of 3-<2,6-dimethoxy-4-(5'-((2)H3)pentyl)phenyl>-4-isopropenyl-1-(((trifluoromethyl)sulfonyl)oxy)cyclohex-1-ene

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Technology Process of 3-<2,6-dimethoxy-4-(5'-((2)H3)pentyl)phenyl>-4-isopropenyl-1-(((trifluoromethyl)sulfonyl)oxy)cyclohex-1-ene

There total 6 articles about 3-<2,6-dimethoxy-4-(5'-((2)H3)pentyl)phenyl>-4-isopropenyl-1-(((trifluoromethyl)sulfonyl)oxy)cyclohex-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38651-65-9
(1R,5S)-(+)-nopinone

: 145104-80-9
3-<2,6-dimethoxy-4-(5'-((2)H3)pentyl)phenyl>-4-isopropenyl-1-(((trifluoromethyl)sulfonyl)oxy)cyclohex-1-ene

Guidance literature:: Multi-step reaction with 6 steps

1: 55 percent / N-bromosuccinimide, (PhCO₂)2 / CCl₄ / 48 h / Heating

2: 76 percent / Li₂CO₃, LiBr / dimethylformamide / 6 h / 130 °C

3: 1) n-BuLi, 2) lithium 2-thienylcyanocuprate, 3) BF₃*Et₂O / 1) THF, hexane, a) 0 deg C, 10 min b) 25 deg C, 2,5 h, 2) -78 deg C, 3) THF, -78 deg C, 5-6 h

4: 65 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 60 h / 22 °C

5: 71 percent / 50percent aq. HClO₄ / acetone / 48 h / 40 °C

6: Li-dimethyl cuprate / 1) ether, 0 deg C, 2) DME, 0 deg C, 5 h

With N-Bromosuccinimide; n-butyllithium; perchloric acid; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; lithium dimethylcuprate; lithium carbonate; thien-2-yl(cyano)copper lithium; lithium bromide; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)85608-8

Reference yield:

: 58738-65-1
1,3-dimethoxy-5-[5'-(2H₃)-pentyl]benzene

: 145104-80-9
3-<2,6-dimethoxy-4-(5'-((2)H3)pentyl)phenyl>-4-isopropenyl-1-(((trifluoromethyl)sulfonyl)oxy)cyclohex-1-ene

Guidance literature:: Multi-step reaction with 4 steps

1: 1) n-BuLi, 2) lithium 2-thienylcyanocuprate, 3) BF₃*Et₂O / 1) THF, hexane, a) 0 deg C, 10 min b) 25 deg C, 2,5 h, 2) -78 deg C, 3) THF, -78 deg C, 5-6 h

2: 65 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 60 h / 22 °C

3: 71 percent / 50percent aq. HClO₄ / acetone / 48 h / 40 °C

4: Li-dimethyl cuprate / 1) ether, 0 deg C, 2) DME, 0 deg C, 5 h

With n-butyllithium; perchloric acid; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; lithium dimethylcuprate; thien-2-yl(cyano)copper lithium; In dichloromethane; acetone;
DOI:10.1016/S0040-4020(01)85608-8

Reference yield:

: 145104-71-8
(1R,5R)-3-bromo-6,6-dimethylbicyclo<3.1.1>-hept-3-en-2-one

: 145104-80-9
3-<2,6-dimethoxy-4-(5'-((2)H3)pentyl)phenyl>-4-isopropenyl-1-(((trifluoromethyl)sulfonyl)oxy)cyclohex-1-ene

Guidance literature:: Multi-step reaction with 4 steps

1: 1) n-BuLi, 2) lithium 2-thienylcyanocuprate, 3) BF₃*Et₂O / 1) THF, hexane, a) 0 deg C, 10 min b) 25 deg C, 2,5 h, 2) -78 deg C, 3) THF, -78 deg C, 5-6 h

2: 65 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 60 h / 22 °C

3: 71 percent / 50percent aq. HClO₄ / acetone / 48 h / 40 °C

4: Li-dimethyl cuprate / 1) ether, 0 deg C, 2) DME, 0 deg C, 5 h

With n-butyllithium; perchloric acid; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; lithium dimethylcuprate; thien-2-yl(cyano)copper lithium; In dichloromethane; acetone;
DOI:10.1016/S0040-4020(01)85608-8