[3-(4-chlorophenylsulfanyl)-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl]acetic acid

Base Information

Chemical Name:[3-(4-chlorophenylsulfanyl)-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl]acetic acid
CAS No.:1260673-36-6
Molecular Formula:C₁₇H₁₆ClNO₃S
Molecular Weight:349.838
Hs Code.:

Synonyms:[3-(4-chlorophenylsulfanyl)-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl]acetic acid

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Chemical Property of [3-(4-chlorophenylsulfanyl)-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl]acetic acid

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Technology Process of [3-(4-chlorophenylsulfanyl)-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl]acetic acid

There total 5 articles about [3-(4-chlorophenylsulfanyl)-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1260673-31-1
ethyl [3-(4-chlorophenylsulfanyl)-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl]acetate

: 1260673-36-6
[3-(4-chlorophenylsulfanyl)-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl]acetic acid

Guidance literature:: With methanol; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1142-19-4
4,4'-dichlorodiphenyl disulfide

: 1260673-37-7
2-(2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)acetic acid

: 1260673-36-6
[3-(4-chlorophenylsulfanyl)-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl]acetic acid

Guidance literature:: 4,4'-dichlorodiphenyl disulfide; With sulfuryl dichloride; In ethyl acetate; at 20 ℃; for 1h; Inert atmosphere;

2-(2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)acetic acid; In ethyl acetate; at 20 ℃; for 1.08333h; Inert atmosphere;

Reference yield:

: 504-02-9
1,3-cylohexanedione

: 1260673-36-6
[3-(4-chlorophenylsulfanyl)-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol; water / 0.5 h / 20 - 30 °C / Inert atmosphere

1.2: 19 h / 20 °C / Inert atmosphere

2.1: sodium acetate / ethanol; water / 2 h / Reflux; Inert atmosphere; Industry scale

3.1: sulfuryl dichloride / ethyl acetate / 5 °C / Inert atmosphere

3.2: 1.67 h / 5 - 20 °C / Inert atmosphere

4.1: lithium hydroxide; methanol / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With methanol; sulfuryl dichloride; sodium acetate; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; ethanol; water; ethyl acetate;