5-(4'-cyanophenyl)-25,26,27,28-tetrahydroxy-11,17,23-trisulfonatocalix[4]arene

Base Information

• Chemical Name: 5-(4'-cyanophenyl)-25,26,27,28-tetrahydroxy-11,17,23-trisulfonatocalix[4]arene
• CAS No.: 1365530-39-7
• Molecular Formula: C₃₅H₂₇NO₁₃S₃
• Molecular Weight: 765.796
• Mol file: 1365530-39-7.mol

Synonyms:5-(4'-cyanophenyl)-25,26,27,28-tetrahydroxy-11,17,23-trisulfonatocalix[4]arene

Chemical Property of 5-(4'-cyanophenyl)-25,26,27,28-tetrahydroxy-11,17,23-trisulfonatocalix[4]arene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4'-cyanophenyl)-25,26,27,28-tetrahydroxy-11,17,23-trisulfonatocalix[4]arene

There total 5 articles about 5-(4'-cyanophenyl)-25,26,27,28-tetrahydroxy-11,17,23-trisulfonatocalix[4]arene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

5-bromo-25,26,27,28-tetrahydroxy-11,17,23-trisulfonatocalix[4]arene (1365530-33-1) + 4-cyanophenylboronic acid (126747-14-6) → 5-(4'-cyanophenyl)-25,26,27,28-tetrahydroxy-11,17,23-trisulfonatocalix[4]arene (1365530-39-7) + 5-(4'-carboxamidophenyl)-25,26,27,28-tetrahydroxy-11,17,23-trisulfonatocalix[4]arene (1365530-40-0)

Guidance literature:

With tetrabutylammomium bromide; water; palladium diacetate; sodium carbonate; at 150 ℃; for 0.0833333h; Microwave irradiation; Sealed vessel;

DOI:10.1021/ol300243b

Reference yield: 29.0%

→ 5-(4'-cyanophenyl)-25,26,27,28-tetrahydroxy-11,17,23-trisulfonatocalix[4]arene (1365530-39-7)

Guidance literature:

With tetrabutylammomium bromide; palladium diacetate; sodium carbonate; In water; Microwave irradiation;

Reference yield:

5-bromo-25,26,27,28-tetrahydroxy-calix[4]arene (317813-41-5,176098-92-3) → 5-(4'-cyanophenyl)-25,26,27,28-tetrahydroxy-11,17,23-trisulfonatocalix[4]arene (1365530-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / dichloromethane / 1 h / 60 °C

2: tetrabutylammomium bromide; water; palladium diacetate; sodium carbonate / 0.08 h / 150 °C / Microwave irradiation; Sealed vessel

With sulfuric acid; tetrabutylammomium bromide; water; palladium diacetate; sodium carbonate; In dichloromethane; 2: Suzuki coupling;

DOI:10.1021/ol300243b

upstream raw materials:

5-bromo-25,26,27,28-tetrahydroxy-11,17,23-trisulfonatocalix[4]arene

4-cyanophenylboronic acid

25,26,27-tris(benzoyloxy)-28-hydroxycalix[4]arene

5-bromo-25,26,27,28-tetrahydroxy-calix[4]arene