(S)-3-(benzyloxy)-2-(4-nitro-N-(prop-2-yn-1-yl)phenylsulfonamido)propanamide

Base Information

Chemical Name:(S)-3-(benzyloxy)-2-(4-nitro-N-(prop-2-yn-1-yl)phenylsulfonamido)propanamide
CAS No.:1313239-36-9
Molecular Formula:C₁₉H₁₉N₃O₆S
Molecular Weight:417.442
Hs Code.:

Synonyms:(S)-3-(benzyloxy)-2-(4-nitro-N-(prop-2-yn-1-yl)phenylsulfonamido)propanamide

Suppliers and Price of (S)-3-(benzyloxy)-2-(4-nitro-N-(prop-2-yn-1-yl)phenylsulfonamido)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(benzyloxy)-2-(4-nitro-N-(prop-2-yn-1-yl)phenylsulfonamido)propanamide

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Technology Process of (S)-3-(benzyloxy)-2-(4-nitro-N-(prop-2-yn-1-yl)phenylsulfonamido)propanamide

There total 6 articles about (S)-3-(benzyloxy)-2-(4-nitro-N-(prop-2-yn-1-yl)phenylsulfonamido)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1386995-56-7
(S)-3-(benzyloxy)-2-(4-nitrophenylsulfonamido)propanamide

: 106-96-7
propargyl bromide

: 1313239-36-9
(S)-3-(benzyloxy)-2-(4-nitro-N-(prop-2-yn-1-yl)phenylsulfonamido)propanamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c2ob25111f

Reference yield:

: 1386995-54-5
(S)-methyl 3-(benzyloxy)-2-(4-nitrophenylsulfonamido)propanoate

: 1313239-36-9
(S)-3-(benzyloxy)-2-(4-nitro-N-(prop-2-yn-1-yl)phenylsulfonamido)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / 1,4-dioxane; water / 52 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere

With ammonia; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25111f

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1313239-36-9
(S)-3-(benzyloxy)-2-(4-nitro-N-(prop-2-yn-1-yl)phenylsulfonamido)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.5 h / 0 °C / Inert atmosphere

2: trifluorormethanesulfonic acid / 1,4-dioxane / 1.5 h / 20 °C / Inert atmosphere

3: ammonia / 1,4-dioxane; water / 52 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere

With trifluorormethanesulfonic acid; ammonia; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25111f