N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycine

Base Information

Chemical Name:N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycine
CAS No.:1334607-45-2
Molecular Formula:C₂₆H₃₀ClN₃O₃
Molecular Weight:467.996
Hs Code.:

Synonyms:N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycine

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Chemical Property of N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycine

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Technology Process of N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycine

There total 6 articles about N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334608-25-1
methyl N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycinate

: 1334607-45-2
N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycine

Guidance literature:: methyl N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycinate; With water; sodium hydroxide; In isopropyl alcohol; at 20 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In water; pH=5;

Reference yield:

: 1260023-43-5
2-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

: 1334607-45-2
N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C

2.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Biotage initiator

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

4.1: hydrogenchloride / water; tetrahydrofuran / 6 h / 70 °C / Inert atmosphere

5.1: sodium acetate; acetic acid / methanol / 0.5 h / 20 °C / Inert atmosphere

5.2: 20 °C

6.1: sodium hydroxide; water / isopropyl alcohol / 2 h / 20 °C / Inert atmosphere

6.2: pH 5

With hydrogenchloride; potassium phosphate; potassium tert-butylate; water; sodium acetate; caesium carbonate; acetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1260024-46-1
2-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1334607-45-2
N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Biotage initiator

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

3.1: hydrogenchloride / water; tetrahydrofuran / 6 h / 70 °C / Inert atmosphere

4.1: sodium acetate; acetic acid / methanol / 0.5 h / 20 °C / Inert atmosphere

4.2: 20 °C

5.1: sodium hydroxide; water / isopropyl alcohol / 2 h / 20 °C / Inert atmosphere

5.2: pH 5

With hydrogenchloride; potassium phosphate; water; sodium acetate; caesium carbonate; acetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; isopropyl alcohol;