methyl N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycinate

Base Information

Chemical Name:methyl N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycinate
CAS No.:1334608-25-1
Molecular Formula:C₂₇H₃₂ClN₃O₃
Molecular Weight:482.022
Hs Code.:

Synonyms:methyl N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycinate

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Chemical Property of methyl N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycinate

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Technology Process of methyl N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycinate

There total 5 articles about methyl N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5473-12-1
N-methylglycine methylester

: 1334608-17-1
[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]acetaldehyde

: 1334608-25-1
methyl N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycinate

Guidance literature:: N-methylglycine methylester; [3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]acetaldehyde; With sodium acetate; acetic acid; In methanol; at 20 ℃; for 0.5h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

: 1260023-43-5
2-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

: 1334608-25-1
methyl N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C

2.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Biotage initiator

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

4.1: hydrogenchloride / water; tetrahydrofuran / 6 h / 70 °C / Inert atmosphere

5.1: sodium acetate; acetic acid / methanol / 0.5 h / 20 °C / Inert atmosphere

5.2: 20 °C

With hydrogenchloride; potassium phosphate; potassium tert-butylate; sodium acetate; caesium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1260024-46-1
2-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1334608-25-1
methyl N-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]ethyl}-N-methylglycinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Biotage initiator

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

3.1: hydrogenchloride / water; tetrahydrofuran / 6 h / 70 °C / Inert atmosphere

4.1: sodium acetate; acetic acid / methanol / 0.5 h / 20 °C / Inert atmosphere

4.2: 20 °C

With hydrogenchloride; potassium phosphate; sodium acetate; caesium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;