Technology Process of di-tert-butyl 5-deazaisofolate
There total 1 articles about di-tert-butyl 5-deazaisofolate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 78 percent / H2 / 10percent Pd/C / dimethylformamide; 2-methoxy-ethanol / 1 h / 2172.02 Torr / Ambient temperature
2: 1.) 3-Angstroem molecular sieve, AcOH, 2.) (CH3)3CNH2*BH3 / 1.) RT, 18 h, 2.) a) RT, 2 h, b) 80 deg C, 2 h
With
3 A molecular sieve; N-tert-butylaminoborane; hydrogen; acetic acid;
palladium on activated charcoal;
In
2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00106a021
- Guidance literature:
-
With
trifluoroacetic acid;
for 2h;
Ambient temperature;
DOI:10.1021/jm00106a021
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 66 percent / CF3COOH / 2 h / Ambient temperature
2: 56 percent / 1 N HCl, NaB(CN)H3 / aq. NaOH / 21.5 h / pH 6.4
3: 75 percent / CF3COOH, H2 / PtO2 / 18 h / 25 °C / 2585.7 Torr
With
hydrogenchloride; hydrogen; sodium cyanoborohydride; trifluoroacetic acid;
platinum(IV) oxide;
In
sodium hydroxide;
DOI:10.1021/jm00106a021
