(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}-3-methylazetidin-3-ol

Base Information

Chemical Name:(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}-3-methylazetidin-3-ol
CAS No.:1239361-87-5
Molecular Formula:C₂₁H₂₀FN₇O
Molecular Weight:405.435
Hs Code.:

Synonyms:(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}-3-methylazetidin-3-ol

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Chemical Property of (S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}-3-methylazetidin-3-ol

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Technology Process of (S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}-3-methylazetidin-3-ol

There total 5 articles about (S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}-3-methylazetidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5049-61-6
2-Aminopyrazine

: 1239363-29-1
3-[6-chloro-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl]-4-(4-fluorophenyl)oxazolidin-2-one

: 1239361-87-5
(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}-3-methylazetidin-3-ol

Guidance literature:: With sodium t-butanolate; XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In 1,4-dioxane; at 90 ℃; for 1h; Inert atmosphere;

Reference yield:

: 5049-61-6
2-Aminopyrazine

: C₁₇H₁₆ClFN₄O

: 1239361-87-5
(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}-3-methylazetidin-3-ol

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium t-butanolate; XPhos; In 1,4-dioxane; at 90 ℃; for 1h;

Reference yield:

: 140373-17-7
α-hydroxymethyl-4-fluorobenzylamine

: 1239361-87-5
(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)pyrimidinecarboxylic-4-yl}-3-methylazetidin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / 2.5 h / 130 °C

2: potassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 5 h / 90 °C / Inert atmosphere

3: sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos / 1,4-dioxane / 1 h / 90 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium phosphate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; XPhos; In 1,4-dioxane;