6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)quinoline

Base Information

Chemical Name:6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)quinoline
CAS No.:1599467-89-6
Molecular Formula:C₂₅H₂₀ClF₃N₂O₃
Molecular Weight:488.894
Hs Code.:

Synonyms:6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)quinoline

Suppliers and Price of 6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)quinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)quinoline

There total 8 articles about 6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1355052-60-6
2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-5-(trifluoromethyl)pyridine

: 1354745-86-0
6-chloro-4-ethoxy-3-iodo-7-methoxy-2-methylquinoline

: 1599467-89-6
6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)quinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; N,N-dimethyl-formamide; at 85 ℃; for 18h;
DOI:10.1021/jm500147k

Reference yield:

: C₁₃H₁₆ClNO₃

: 1599467-89-6
6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)quinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: dowtherm A / 0.33 h / 250 °C

2.1: iodine; potassium iodide; N-butylamine / water; N,N-dimethyl-formamide / 12 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C

3.2: 8 h / 50 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 85 °C

With dowtherm A; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; potassium carbonate; N-butylamine; potassium iodide; In water; N,N-dimethyl-formamide; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500147k

Reference yield:

: 106-41-2
4-bromo-phenol

: 1599467-89-6
6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; 2-Picolinic acid; potassium phosphate / dimethyl sulfoxide / 18 h / 80 °C

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / N,N-dimethyl-formamide / 18 h / 80 °C / Molecular sieve

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 85 °C

With 2-Picolinic acid; potassium phosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; potassium carbonate; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; 3: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500147k