2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-5-(trifluoromethyl)pyridine

Base Information

Chemical Name:2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-5-(trifluoromethyl)pyridine
CAS No.:1355052-60-6
Molecular Formula:C₁₈H₁₉BF₃NO₃
Molecular Weight:365.16
Hs Code.:

Synonyms:2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-5-(trifluoromethyl)pyridine

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Chemical Property of 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-5-(trifluoromethyl)pyridine

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Technology Process of 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-5-(trifluoromethyl)pyridine

There total 5 articles about 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-5-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 137736-63-1
2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine

: 73183-34-3
bis(pinacol)diborane

: 1355052-60-6
2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-5-(trifluoromethyl)pyridine

Guidance literature:: With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; In N,N-dimethyl-formamide; at 80 ℃; for 18h; Molecular sieve;
DOI:10.1021/jm500147k

Reference yield:

: 69045-82-5
2-fluoro-5-(trifluoromethyl)pyridine

: 269409-70-3
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1355052-60-6
2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-5-(trifluoromethyl)pyridine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 160 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 106-41-2
4-bromo-phenol

: 1355052-60-6
2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-5-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; 2-Picolinic acid; potassium phosphate / dimethyl sulfoxide / 18 h / 80 °C

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / N,N-dimethyl-formamide / 18 h / 80 °C / Molecular sieve

With 2-Picolinic acid; potassium phosphate; copper(l) iodide; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm500147k