5-cyano-2-methyl-6-thioxo-1,6-dihydropyridine-3-carboxylic acid phenyl amide

Base Information

• Chemical Name: 5-cyano-2-methyl-6-thioxo-1,6-dihydropyridine-3-carboxylic acid phenyl amide
• CAS No.: 301298-00-0
• Molecular Formula: C₁₄H₁₁N₃OS
• Molecular Weight: 269.327
• Mol file: 301298-00-0.mol

Synonyms:5-cyano-2-methyl-6-thioxo-1,6-dihydropyridine-3-carboxylic acid phenyl amide

Chemical Property of 5-cyano-2-methyl-6-thioxo-1,6-dihydropyridine-3-carboxylic acid phenyl amide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-cyano-2-methyl-6-thioxo-1,6-dihydropyridine-3-carboxylic acid phenyl amide

There total 2 articles about 5-cyano-2-methyl-6-thioxo-1,6-dihydropyridine-3-carboxylic acid phenyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Cyanothioacetamide (7357-70-2) + 2-((dimethylamino)methylene)-3-oxo-N-phenylbutanamide (474369-11-4) → 5-cyano-2-methyl-6-thioxo-1,6-dihydropyridine-3-carboxylic acid phenyl amide (301298-00-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

DOI:10.1055/s-0031-1289633

Reference yield: 86.0%

Cyanothioacetamide (7357-70-2) + 3-ethoxy-2-formyl-N-phenyl-acrylamide → 5-cyano-2-methyl-6-thioxo-1,6-dihydropyridine-3-carboxylic acid phenyl amide (301298-00-0)

Guidance literature:

With 4-methyl-morpholine; In ethanol; at 25 ℃; for 2h;

DOI:10.1023/A:1011981716490

Reference yield: 92.0%

propyl bromide (106-94-5) + 5-cyano-2-methyl-6-thioxo-1,6-dihydropyridine-3-carboxylic acid phenyl amide (301298-00-0) → 5-cyano-2-methyl-N-phenyl-6-propylsulfanyl-nicotinamide

Guidance literature:

5-cyano-2-methyl-6-thioxo-1,6-dihydropyridine-3-carboxylic acid phenyl amide; With potassium hydroxide; In N,N-dimethyl-formamide; for 0.0833333h;

propyl bromide; In N,N-dimethyl-formamide; for 4h;

DOI:10.1023/A:1011981716490

upstream raw materials:

Cyanothioacetamide

2-((dimethylamino)methylene)-3-oxo-N-phenylbutanamide

Downstream raw materials:

3-amino-6-methylthieno[2,3-b]pyridine-2,5-dicarboxylic acid 2-dimethylamide 5-phenylamide

ethyl 3-amino-6-methyl-5-(phenylcarbamoyl)thieno[2,3-b]pyridine-2-carboxylate

3-amino-2-cyano-6-methyl-N-phenylthieno[2,3-b]pyridine-5-carboxamide