{(1R)-1-[(2S)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl} 3,5-dinitrobenzoate

Base Information

Chemical Name:{(1R)-1-[(2S)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl} 3,5-dinitrobenzoate
CAS No.:188645-03-6
Molecular Formula:C₁₇H₁₂F₂N₂O₇
Molecular Weight:394.288
Hs Code.:

Synonyms:{(1R)-1-[(2S)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl} 3,5-dinitrobenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {(1R)-1-[(2S)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl} 3,5-dinitrobenzoate

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Technology Process of {(1R)-1-[(2S)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl} 3,5-dinitrobenzoate

There total 1 articles about {(1R)-1-[(2S)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl} 3,5-dinitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.4%

: (1R)-1-[2-(2,4-difluorophenyl)-2-oxiranyl]ethanol

: 99-33-2
3,5-dinitrobenoyl chloride

: 150802-97-4
[(1R)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl] 3,5-dinitrobenzoate

: 188645-03-6
{(1R)-1-[(2S)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl} 3,5-dinitrobenzoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h; Yield given;
DOI:10.1248/cpb.45.321

Reference yield: 100.0%

: 188645-03-6
{(1R)-1-[(2S)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl} 3,5-dinitrobenzoate

: 150802-86-1
(1R)-1-<(2S)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol

Guidance literature:: With sodium hydroxide; In methanol; for 0.666667h;
DOI:10.1248/cpb.45.321

Reference yield:

: 188645-03-6
{(1R)-1-[(2S)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl} 3,5-dinitrobenzoate

: 138373-69-0
(1S)-1-<(2S)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / 1 N aq. NaOH / methanol / 0.67 h

2: 96 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 16 h

3: 96 percent / 28percent NaOMe, MeOH / 4 h

With methanol; sodium hydroxide; sodium methylate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.45.321