[(1R)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl] 3,5-dinitrobenzoate

Base Information

• Chemical Name: [(1R)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl] 3,5-dinitrobenzoate
• CAS No.: 150802-97-4
• Molecular Formula: C₁₇H₁₂F₂N₂O₇
• Molecular Weight: 394.288

Synonyms:[(1R)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl] 3,5-dinitrobenzoate

Chemical Property of [(1R)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl] 3,5-dinitrobenzoate

Chemical Property:

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Technology Process of [(1R)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl] 3,5-dinitrobenzoate

There total 5 articles about [(1R)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl] 3,5-dinitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

(1R)-1-[2-(2,4-difluorophenyl)-2-oxiranyl]ethanol + 3,5-dinitrobenoyl chloride (99-33-2) → [(1R)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl] 3,5-dinitrobenzoate (150802-97-4)

Guidance literature:

With triethylamine; In dichloromethane; for 3.5h;

DOI:10.1248/cpb.44.314

Reference yield: 7.4%

(1R)-1-[2-(2,4-difluorophenyl)-2-oxiranyl]ethanol + 3,5-dinitrobenoyl chloride (99-33-2) → [(1R)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl] 3,5-dinitrobenzoate (150802-97-4) + {(1R)-1-[(2S)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl} 3,5-dinitrobenzoate (188645-03-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h; Yield given;

DOI:10.1248/cpb.45.321

Reference yield:

(2S,3R)-3-(2,4-Difluorophenyl)-3,4-epoxy-2-butanol (150802-96-3) + 3,5-dinitrobenoyl chloride (99-33-2) → [(1R)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl] 3,5-dinitrobenzoate (150802-97-4)

Guidance literature:

With trimethylamine; In methanol; dichloromethane; ethyl acetate;

upstream raw materials:

3,5-dinitrobenoyl chloride

2-[(1R)-1-(3,4,5,6-Tetrahydro-2H-pyran-2-yl)oxyethyl]-2-(2,4-difluorophenyl)oxirane

(2S,3R)-3-(2,4-Difluorophenyl)-3,4-epoxy-2-butanol

Downstream raw materials:

(1S)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol

(R)-1-[(R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl methanesulfonate

(2S)-2-(2,4-difluorophenyl)-2-<(1R)-1-(2H-tetrazol-2-yl)ethyl>oxirane

(2S)-2-(2,4-difluorophenyl)-2-<(1R)-1-(1H-tetrazol-1-yl)ethyl>oxirane

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